Song Xin, Guo Yanan, Song Peng, Duan Dongzhu, Guo Wenjing
School of Life Sciences and Engineering, Lanzhou University of Technology, Lanzhou, China.
School of Traditional Chinese and Western Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, China.
Front Cell Dev Biol. 2021 Sep 20;9:751578. doi: 10.3389/fcell.2021.751578. eCollection 2021.
Non-coding RNAs (ncRNAs) are RNAs that do not encode proteins, but perform biological functions in various physiological and pathological processes, including cancer formation, inflammation, and neurological diseases. Tumor blood vessels are a key target for cancer management. A number of factors regulate the angiogenesis of malignant tumors. NcRNAs participate in the regulation of tumor angiogenesis. Abnormal expression of ncRNAs act as tumor suppressors or oncogenes to affect the development of tumors. In this review we summarized the biological functions of ncRNAs, and discussed its regulatory mechanisms in tumor angiogenesis. This article will provide new insights for the research of ncRNAs in tumor angiogenesis.
非编码RNA（ncRNAs）是一类不编码蛋白质的RNA，但在各种生理和病理过程中发挥生物学功能，包括癌症形成、炎症和神经疾病。肿瘤血管是癌症治疗的关键靶点。许多因素调节恶性肿瘤的血管生成。ncRNAs参与肿瘤血管生成的调控。ncRNAs的异常表达可作为肿瘤抑制因子或癌基因影响肿瘤的发展。在本综述中，我们总结了ncRNAs的生物学功能，并讨论了其在肿瘤血管生成中的调控机制。本文将为ncRNAs在肿瘤血管生成方面的研究提供新的见解。
