Wang Xing, Zhang Zhengjiao, Lan Xiaoxin, Fu Keyou, Xu Guanhua, Zhao Jingyi, Yuan Haibo
Department of Respiratory Medicine and Sleep Center, First Hospital of Jilin University, Changchun 130021, China.
Department of Neurology and Sleep Center, People's Hospital of Jilin Province, Changchun, China.
Int J Hypertens. 2021 Nov 11;2021:4717349. doi: 10.1155/2021/4717349. eCollection 2021.
Despite approximately 95% primary cases of hypertension, secondary hypertension seems to be common with resistant forms. Notably, obstructive sleep apnea (OSA) is known as a common cause of secondary hypertension and has a major characteristic of obesity. Irisin acts as a link between muscles and adipose tissues in obesity, playing an essential role in human blood pressure (BP) regulation. However, whether irisin is associated with secondary hypertension caused by OSA and how it takes effect essentially have not been elucidated.
To investigate the changes of irisin and its relationship with BP in OSA.
72 snoring patients finished Epworth Sleep Scale (ESS) evaluation before polysomnography (PSG). BP was the average of three brachial BP values by mercury sphygmomanometer. Serum irisin level was determined by enzyme-linked immunosorbent assay (ELISA). Results were analyzed by SPSS software.
Irisin was higher in the severe and quite severe group than that in control and nonsevere groups ( < 0.05). For BP, significant differences were found between the control group and the other three groups ( < 0.05) and between the quite severe and the other three groups ( ≤ 0.001). Positive correlations were found between irisin and apnea-hypopnea index (AHI), AHI and BP, and irisin level and BP. Negative correlations were between irisin and SpO nadir and SpO nadir and BP. Positive correlation still existed between AHI and irisin even after adjusting for some obesity-related variables.
Irisin may serve as a potential biomarker for severity of OSA independently of obesity and imply the development of hypertension.
尽管约95%的高血压为原发性病例，但继发性高血压在难治性类型中似乎很常见。值得注意的是，阻塞性睡眠呼吸暂停（OSA）是继发性高血压的常见病因，且具有肥胖这一主要特征。鸢尾素在肥胖状态下充当肌肉与脂肪组织之间的联系纽带，在人体血压（BP）调节中发挥着重要作用。然而，鸢尾素是否与OSA所致的继发性高血压相关以及其具体作用机制尚未阐明。
探讨OSA患者中鸢尾素的变化及其与血压的关系。
72例打鼾患者在多导睡眠图（PSG）检查前完成爱泼沃斯思睡量表（ESS）评估。血压采用汞柱式血压计测量三次肱动脉血压值的平均值。血清鸢尾素水平通过酶联免疫吸附测定（ELISA）法测定。结果采用SPSS软件进行分析。
重度和相当重度组的鸢尾素水平高于对照组和非重度组（<0.05）。血压方面，对照组与其他三组之间存在显著差异（<0.05），相当重度组与其他三组之间也存在显著差异（≤0.001）。鸢尾素与呼吸暂停低通气指数（AHI）、AHI与血压以及鸢尾素水平与血压之间均呈正相关。鸢尾素与最低血氧饱和度（SpO₂ nadir）以及SpO₂ nadir与血压之间呈负相关。即使在调整了一些与肥胖相关的变量后，AHI与鸢尾素之间仍存在正相关。
鸢尾素可能是独立于肥胖之外的OSA严重程度的潜在生物标志物，并提示高血压的发生。
