Ghafouri-Fard Soudeh, Khanbabapour Sasi Ali, Abak Atefe, Shoorei Hamed, Khoshkar Ali, Taheri Mohammad
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Biochemistry Group, School of Medicine, Golestan University of Medical Science, Gorgan, Iran.
Front Oncol. 2021 Nov 5;11:768949. doi: 10.3389/fonc.2021.768949. eCollection 2021.
Breast cancer is the most frequently diagnosed cancer among females. Gene expression profiling methods have shown the deregulation of several genes in breast cancer samples and have confirmed the heterogeneous nature of breast cancer at the genomic level. microRNAs (miRNAs) are among the recently appreciated contributors in breast carcinogenic processes. These small-sized transcripts have been shown to partake in breast carcinogenesis through modulation of apoptosis, autophagy, and epithelial-mesenchymal transition. Moreover, they can confer resistance to chemotherapy. Based on the contribution of miRNAs in almost all fundamental aspects of breast carcinogenesis, therapeutic intervention with their expression might affect the course of this disorder. Moreover, the presence of miRNAs in the peripheral blood of patients potentiates these transcripts as tools for non-invasive diagnosis of breast cancer.
乳腺癌是女性中最常被诊断出的癌症。基因表达谱分析方法已显示乳腺癌样本中多个基因的失调，并在基因组水平上证实了乳腺癌的异质性。微小RNA（miRNA）是最近在乳腺癌致癌过程中受到重视的因素之一。这些小尺寸转录本已被证明通过调节细胞凋亡、自噬和上皮-间质转化参与乳腺癌的发生。此外，它们可赋予对化疗的抗性。基于miRNA在乳腺癌发生几乎所有基本方面的作用，对其表达进行治疗干预可能会影响这种疾病的进程。此外，患者外周血中miRNA的存在增强了这些转录本作为乳腺癌非侵入性诊断工具的作用。
