Anekthanakul Krittima, Manocheewa Siriphan, Chienwichai Kittiphan, Poungsombat Patcha, Limjiasahapong Suphitcha, Wanichthanarak Kwanjeera, Jariyasopit Narumol, Mathema Vivek Bhakta, Kuhakarn Chutima, Reutrakul Vichai, Phetcharaburanin Jutarop, Panya Atikorn, Phonsatta Natthaporn, Visessanguan Wonnop, Pomyen Yotsawat, Sirivatanauksorn Yongyut, Worawichawong Suchin, Sathirapongsasuti Nuankanya, Kitiyakara Chagriya, Khoomrung Sakda
Metabolomics and Systems Biology, Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Siriraj Metabolomics and Phenomics Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
iScience. 2021 Oct 25;24(11):103355. doi: 10.1016/j.isci.2021.103355. eCollection 2021 Nov 19.
The current gold standard for classifying lupus nephritis (LN) progression is a renal biopsy, which is an invasive procedure. Undergoing a series of biopsies for monitoring disease progression and treatments is unlikely suitable for patients with LN. Thus, there is an urgent need for non-invasive alternative biomarkers that can facilitate LN class diagnosis. Such biomarkers will be very useful in guiding intervention strategies to mitigate or treat patients with LN. Urine samples were collected from two independent cohorts. Patients with LN were classified into proliferative (class III/IV) and membranous (class V) by kidney histopathology. Metabolomics was performed to identify potential metabolites, which could be specific for the classification of membranous LN. The ratio of picolinic acid (Pic) to tryptophan (Trp) ([Pic/Trp] ratio) was found to be a promising candidate for LN diagnostic and membranous classification. It has high potential as an alternative biomarker for the non-invasive diagnosis of LN.
目前用于分类狼疮性肾炎（LN）进展的金标准是肾活检，这是一种侵入性操作。对LN患者进行一系列活检以监测疾病进展和治疗不太可行。因此，迫切需要能够促进LN分类诊断的非侵入性替代生物标志物。此类生物标志物对于指导LN患者的干预策略以减轻病情或进行治疗将非常有用。从两个独立队列中收集了尿液样本。根据肾脏组织病理学将LN患者分为增殖性（III/IV类）和膜性（V类）。进行代谢组学分析以鉴定潜在的代谢物，这些代谢物可能对膜性LN的分类具有特异性。发现吡啶甲酸（Pic）与色氨酸（Trp）的比率（[Pic/Trp]比率）是LN诊断和膜性分类的一个有前景的候选指标。它作为LN非侵入性诊断的替代生物标志物具有很高的潜力。
