Manthey Jakob, Freeman Tom P, Kilian Carolin, López-Pelayo Hugo, Rehm Jürgen
Center for Interdisciplinary Addiction Research (ZIS), Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246 Hamburg, Germany.
Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Chemnitzer Str. 46, 01187 Dresden, Germany.
Lancet Reg Health Eur. 2021 Sep 24;10:100227. doi: 10.1016/j.lanepe.2021.100227. eCollection 2021 Nov.
Cannabis is one of the most widely used substances worldwide. Heavy use is associated with an increased risk of cannabis use disorders, psychotic disorders, acute cognitive impairment, traffic injuries, respiratory problems, worse pregnancy outcomes, and there are indications for genotoxic and epigenotoxic adverse effects. International regulation of medical and non-medical cannabis use is changing rapidly and substantially, highlighting the importance of robust public health monitoring. This study aimed to describe the trends of key public health indicators in European Union (27 member states + UK, Norway and Turkey) for the period 2010 to 2019, their public health implications, and to identify the steps required to improve current practice in monitoring of cannabis use and harm in Europe.
Data on four key cannabis indicators (prevalence of use, prevalence of cannabis use disorder [CUD], treatment rates, and potency of cannabis products) in Europe were extracted from the United Nations Office on Drugs and Crime, European Monitoring Centre for Drugs and Drug Addiction and the Global Burden of Disease study. For prevalence of use and CUD, the first and last available estimate in each country were compared. For treatment rates and cannabis potency, linear regression models were conducted.
Between 2010 and 2019, past-month prevalence of cannabis use increased by 27% in European adults (from 3·1 to 3·9%), with most pronounced relative increases observed among 35-64 year-olds. In 13 out of 26 countries, over 20% of all past-month users reported high-risk use patterns. The rate of treatment entry for cannabis problems per 100,000 adults increased from 27·0 (95% CI: 17·2 to 36·8) to 35·1 (95% CI: 23·6 to 46·7) and has mostly plateaued since 2015. Modest increases in potency were found in herbal cannabis (from 6·9% to 10·6% THC) while median THC values tripled in cannabis resin (from 7·6% to 24·1% THC).
In the past decade, cannabis use, treatment rates and potency levels have increased in Europe highlighting major concerns about the public health impact of cannabis use. Continued monitoring and efforts to improve data quality and reporting, including indicators of high-risk use and cannabis-attributable harm, will be necessary to evaluate the health impact of international changes in cannabis regulation.
This study received no specific funding.
大麻是全球使用最广泛的物质之一。大量使用大麻会增加患大麻使用障碍、精神障碍、急性认知障碍、交通伤害、呼吸问题的风险,以及出现更差的妊娠结局,并且有迹象表明存在基因毒性和表观遗传毒性等不良反应。医用和非医用大麻使用的国际监管正在迅速且大幅变化,凸显了强有力的公共卫生监测的重要性。本研究旨在描述2010年至2019年期间欧盟(27个成员国+英国、挪威和土耳其)关键公共卫生指标的趋势、其对公共卫生的影响,并确定改善欧洲当前大麻使用及危害监测实践所需采取的步骤。
从联合国毒品和犯罪问题办公室、欧洲毒品和药物成瘾监测中心以及全球疾病负担研究中提取欧洲四种关键大麻指标(使用流行率、大麻使用障碍[CUD]流行率、治疗率和大麻产品效力)的数据。对于使用流行率和CUD,比较了每个国家的首次和最后可得估计值。对于治疗率和大麻效力,进行了线性回归模型分析。
2010年至2019年期间,欧洲成年人过去一个月的大麻使用流行率上升了27%(从3.1%升至3.9%),35至64岁人群的相对增幅最为显著。在26个国家中的13个国家,超过20%的过去一个月使用者报告有高风险使用模式。每10万成年人中因大麻问题进入治疗的比率从27.0(95%置信区间:17.2至36.8)升至35.1(95%置信区间:23.6至46.7),自2015年以来大多趋于平稳。发现草药大麻的效力有适度增加(从6.9%的四氢大麻酚升至10.6%),而大麻树脂中的四氢大麻酚中位数增加了两倍(从7.6%升至24.1%)。
在过去十年中,欧洲的大麻使用、治疗率和效力水平均有所上升,凸显了对大麻使用对公共卫生影响的重大担忧。持续监测并努力提高数据质量和报告水平,包括高风险使用指标和大麻所致危害指标,对于评估大麻监管国际变化对健康的影响将是必要的。
本研究未获得特定资金。