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早期应用体外膜肺氧合治疗心肌炎合并休克:病例报告。

Early application of extracorporeal membrane oxygenation for myocarditis with shock: a case report.

机构信息

Jilin Provincial Cardiovascular Research Institute, Department of Cardiology in the Third Hospital of Jilin University, Jilin, China.

出版信息

J Int Med Res. 2021 Nov;49(11):3000605211058875. doi: 10.1177/03000605211058875.

DOI:10.1177/03000605211058875
PMID:34806922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8647248/
Abstract

The current therapy for myocarditis is immunosuppressive therapy. However, in rare cases in which patients do not respond to intervention, their condition can rapidly deteriorate to myocarditis with shock, which is characterized by extensive and diffuse lymphocyte infiltration in the myocardium. Most cases of myocarditis are caused by virus-mediated damage of cardiomyocytes, and its clinical manifestations are ventricular arrhythmia and hemodynamic disturbances. Extracorporeal membrane oxygenation is an effective intervention, which regulates hemodynamic stability and avoids systemic hypoperfusion. This intervention has been used to sustain hemodynamic stability in patients with myocarditis and shock. We report here early application of extracorporeal membrane oxygenation for successful treatment of a patient with myocarditis and shock.

摘要

目前心肌炎的治疗方法是免疫抑制疗法。然而,在极少数情况下,患者对干预措施没有反应,他们的病情可能会迅速恶化,发展为心肌炎伴休克,其特征是心肌内广泛弥漫的淋巴细胞浸润。大多数心肌炎是由病毒介导的心肌细胞损伤引起的,其临床表现为室性心律失常和血流动力学紊乱。体外膜肺氧合是一种有效的干预措施,可以调节血流动力学稳定性,避免全身低灌注。这种干预措施已被用于维持心肌炎和休克患者的血流动力学稳定。我们在此报告了早期应用体外膜肺氧合成功治疗心肌炎伴休克患者的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2a1/8647248/077572d8b23c/10.1177_03000605211058875-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2a1/8647248/d701639c23e3/10.1177_03000605211058875-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2a1/8647248/cfe1d2e8a88f/10.1177_03000605211058875-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2a1/8647248/077572d8b23c/10.1177_03000605211058875-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2a1/8647248/d701639c23e3/10.1177_03000605211058875-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2a1/8647248/cfe1d2e8a88f/10.1177_03000605211058875-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2a1/8647248/077572d8b23c/10.1177_03000605211058875-fig3.jpg

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本文引用的文献

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Overview of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) Support for the Management of Cardiogenic Shock.静脉-动脉体外膜肺氧合(VA-ECMO)支持治疗心源性休克概述
Front Cardiovasc Med. 2021 Jul 7;8:686558. doi: 10.3389/fcvm.2021.686558. eCollection 2021.
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Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis: JACC Review Topic of the Week.心脏淋巴管在心衰心肌水肿和纤维化中的作用:JACC 本周综述专题
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体外膜肺氧合用于支持急性暴发性心肌炎的儿科患者。
Turk J Pediatr. 2019;61(6):867-872. doi: 10.24953/turkjped.2019.06.007.
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Recognition and Initial Management of Fulminant Myocarditis: A Scientific Statement From the American Heart Association.暴发性心肌炎的识别和初步处理:美国心脏协会的科学声明。
Circulation. 2020 Feb 11;141(6):e69-e92. doi: 10.1161/CIR.0000000000000745. Epub 2020 Jan 6.
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The Clinical Features of Children With Acute Fulminant Myocarditis and the Diagnostic and Follow-Up Value of Cardiovascular Magnetic Resonance.急性暴发性心肌炎患儿的临床特征及心血管磁共振成像的诊断与随访价值
Front Pediatr. 2019 Oct 1;7:388. doi: 10.3389/fped.2019.00388. eCollection 2019.
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Myocardial Tissue Characterization and Fibrosis by Imaging.心肌组织的影像学特征与纤维化
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Int J Cardiol. 2019 Nov 1;294:61-64. doi: 10.1016/j.ijcard.2019.07.046. Epub 2019 Jul 24.
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The spectrum of myocarditis: from pathology to the clinics.心肌炎的谱:从病理学到临床。
Virchows Arch. 2019 Sep;475(3):279-301. doi: 10.1007/s00428-019-02615-8. Epub 2019 Jul 11.
9
Chinese society of cardiology expert consensus statement on the diagnosis and treatment of adult fulminant myocarditis.中华医学会心血管病学分会成人暴发性心肌炎诊断和治疗专家共识。
Sci China Life Sci. 2019 Feb;62(2):187-202. doi: 10.1007/s11427-018-9385-3. Epub 2018 Dec 3.
10
Clinical determinants of successful weaning from extracorporeal membrane oxygenation in patients with fulminant myocarditis.暴发性心肌炎患者体外膜肺氧合撤机成功的临床决定因素。
ESC Heart Fail. 2018 Aug;5(4):675-684. doi: 10.1002/ehf2.12291. Epub 2018 May 14.