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Direct use of eazyplex SuperBug CRE assay from positive blood cultures in conjunction with inpatient infectious disease consulting for timely appropriate antimicrobial therapy in and bloodstream infections.将eazyplex超广谱β-内酰胺酶（ESBL）产酶肠杆菌科细菌（CRE）检测直接用于阳性血培养，并结合住院传染病咨询，以便对[具体医院名称1]和[具体医院名称2]血流感染及时进行适当的抗菌治疗。
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eazyplex® BloodScreen GN 作为一种简单快速的分子检测方法，用于从阳性血培养物中鉴定革兰氏阴性菌的性能。

Performance of the eazyplex® BloodScreen GN as a simple and rapid molecular test for identification of Gram-negative bacteria from positive blood cultures.

机构信息

Institute of Medical Microbiology, Jena University Hospital, Friedrich Schiller University, Jena, Germany.

Division of Infection Control and Infectious Diseases, RWTH Aachen University Hospital, Aachen, Germany.

出版信息

Eur J Clin Microbiol Infect Dis. 2022 Mar;41(3):489-494. doi: 10.1007/s10096-021-04383-3. Epub 2021 Nov 22.

DOI:10.1007/s10096-021-04383-3
PMID:34807364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8831353/
Abstract

The LAMP-based eazyplex® BloodScreen GN was evaluated for the detection of frequent Gram-negatives directly from positive blood culture (BC) bottles. A total of 449 BCs were analyzed. Sensitivities and specificities were 100% and 100% for Escherichia coli, 95.7% and 100% for Klebsiella pneumoniae, 100% and 100% for bla, 100% and 100% for Klebsiella oxytoca, 100% and 99% for Proteus mirabilis, and 100% and 99.8% for Pseudomonas aeruginosa, respectively. The time to result ranged from 8 to 16 min, plus about 6 min for sample preparation. The eazyplex® BloodScreen GN is a reliable molecular assay for rapid BC testing.

摘要

基于 LAMP 的 eazyplex® BloodScreen GN 用于直接从阳性血培养瓶中检测常见革兰氏阴性菌。共分析了 449 个血培养瓶。对于大肠杆菌，灵敏度和特异性均为 100%和 100%；对于肺炎克雷伯菌，灵敏度和特异性均为 95.7%和 100%；对于鲍曼不动杆菌，灵敏度和特异性均为 100%和 100%；对于奇异变形杆菌，灵敏度和特异性均为 100%和 99%；对于铜绿假单胞菌，灵敏度和特异性均为 100%和 99.8%。结果时间为 8 至 16 分钟，加上约 6 分钟的样本制备时间。eazyplex® BloodScreen GN 是一种用于快速血培养检测的可靠分子检测方法。