在利用亲脂性修饰双铱/镍催化剂体系的金属光氧化还原交叉亲电偶联反应中绿色溶剂的应用
Use of Green Solvents in Metallaphotoredox Cross-Electrophile Coupling Reactions Utilizing a Lipophilic Modified Dual Ir/Ni Catalyst System.
作者信息
Delgado Pete, Glass Raoul J, Geraci Gina, Duvadie Rohit, Majumdar Dyuti, Robinson Richard I, Elmaarouf Imran, Mikus Malte, Tan Kian L
机构信息
Global Discovery Chemistry-SynTech Group, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
出版信息
J Org Chem. 2021 Dec 3;86(23):17428-17436. doi: 10.1021/acs.joc.1c02013. Epub 2021 Nov 22.
Facilitating photoredox coupling reactions in process-friendly green solvents was achieved by the successful application of a dual Ir/Ni catalyst system with enhanced solubility properties. These photochemical reactions (specifically Br-Br sp-sp cross electrophile coupling) are reported in a head to head comparison to the standard di--Bu bipyridine ligand Ir/Ni catalyst system. This presentation highlights the benefits of altering the solubility properties of the ligands used in the Ir/Ni dual catalyst.
通过成功应用具有增强溶解性的双铱/镍催化剂体系，在工艺友好的绿色溶剂中实现了光氧化还原偶联反应。这些光化学反应（特别是溴-溴sp-sp交叉亲电偶联反应）与标准的二-叔丁基联吡啶配体铱/镍催化剂体系进行了直接比较。本报告强调了改变铱/镍双催化剂中所用配体溶解性的好处。
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