Department of Anesthesiology and Reanimation, Şişli Hamidiye Etfal Training and Research Hospital, Halaskargazi caddesi, 34371, Şişli, Istanbul, Turkey.
BMC Anesthesiol. 2021 Nov 22;21(1):291. doi: 10.1186/s12871-021-01511-6.
Older adults have an increased risk of mortality from Coronavirus disease 2019 (Covid-19). Despite the high number of publications on the topic of Covid-19 pandemic, few studies have focused on the intensive care treatments of Covid-19 patients aged 80 years and older. The goal of our study is to investigate the effect of the intensive care treatments on the mortality of Covid-19 patients aged 80 years and older based on their clinical features, laboratory findings and the intensive care treatments methods.
The data of 174 patients aged 80 years and older treated from Covid-19 in intensive care unit were assessed retrospectively. The patients were divided into two groups as survivor and non-survivor. The effects of age, gender, length of stay, comorbid diseases, laboratory values, thoracic computed tomography findings, having invasive mechanical ventilation (IMV), high flow nasal cannula (HFNC) and/or non-invasive mechanical ventilation (NIMV), hemodiafiltration (HDF), anti-cytokines and plasma therapy on mortality have been investigated.
The mean age and mean values of CRP, PCT, Ferritin, LDH were statistically significantly high in the non-survivor group. The mortality rate of the patients who had IMV was also statistically significantly higher compared to patients who had HFNC and/or NIMV. Albumin level and the rate of treatment with HFNC and/or NIMV were statistically significantly low in non-survivor group compared to the Survivor group.
ICU treatments may be beneficial for the Covid-19 patients aged 80 years and older. Increased age, high levels of CRP, PCT, ferritin, and having IMV are detected as poor outcome markers.
老年人因 2019 年冠状病毒病（Covid-19）而死亡的风险增加。尽管关于 Covid-19 大流行的出版物很多，但很少有研究关注 80 岁及以上的 Covid-19 患者的重症监护治疗。我们的研究目的是根据 80 岁及以上的 Covid-19 患者的临床特征、实验室检查结果和重症监护治疗方法，研究重症监护治疗对他们的死亡率的影响。
回顾性评估了 174 名在重症监护病房接受 Covid-19 治疗的 80 岁及以上患者的数据。将患者分为存活组和非存活组。研究了年龄、性别、住院时间、合并症、实验室值、胸部计算机断层扫描结果、有无有创机械通气（IMV）、高流量鼻导管（HFNC）和/或无创机械通气（NIMV）、血液透析滤过（HDF）、抗细胞因子和血浆治疗对死亡率的影响。
非存活组的平均年龄和 CRP、PCT、铁蛋白、LDH 的平均值明显较高。与接受 HFNC 和/或 NIMV 治疗的患者相比，接受 IMV 治疗的患者的死亡率也明显更高。与存活组相比，非存活组的白蛋白水平和接受 HFNC 和/或 NIMV 治疗的比例明显较低。
重症监护治疗可能对 80 岁及以上的 Covid-19 患者有益。年龄增加、CRP、PCT、铁蛋白水平升高和接受 IMV 治疗被认为是预后不良的标志物。
