KOSA Pharma GmbH, Frankfurt am Main, Germany.
Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
J Transl Med. 2021 Nov 22;19(1):471. doi: 10.1186/s12967-021-03143-3.
There is accumulating evidence of endothelial dysfunction, muscle and cerebral hypoperfusion in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In this paper we deduce the pathomechanisms resulting in central nervous pathology and the myriad of neurocognitive symptoms. We outline tentative mechanisms of impaired cerebral blood flow, increase in intracranial pressure and central adrenergic hyperactivity and how they can well explain the key symptoms of cognitive impairment, brain fog, headache, hypersensitivity, sleep disturbances and dysautonomia.
越来越多的证据表明，肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）存在内皮功能障碍、肌肉和大脑灌注不足。本文推论了导致中枢神经系统病理和多种神经认知症状的发病机制。我们概述了脑血流受损、颅内压升高和中枢去甲肾上腺素活性亢进的推测机制，以及它们如何能很好地解释认知障碍、脑雾、头痛、过敏、睡眠障碍和自主神经功能紊乱等关键症状。
