Wehner F C, Marasas W F, Thiel P G
Appl Environ Microbiol. 1978 Apr;35(4):659-62. doi: 10.1128/aem.35.4.659-662.1978.
The mutagenicity of eight Fusarium toxins (mono-, di-, and triacetoxyscirpenol, T-2 toxin, deoxynivalenol, 3-acetyl-deoxynivalenol, zearalenone, and moniliformin) and of two positive controls (aflatoxin B1 and sterigmatocystin) to histidine-requiring strains TA 98, 100, 1535, and 1537 of Salmonella typhimurium was tested both with and without metabolic activation. Both aflatoxin B1 and sterigmatocystin, but none of the eight Fusarium toxins, were mutagenic to S. typhimurium. The lack of mutagenic activity of T-2 toxin and diacetoxyscirpenol supports the negative results that have been obtained with in vivo carcinogenicity tests. The negative mutagenicity of the four other 12,13-epoxytrichothecenes tested, and of zearalenone and moniliformin, could not be correlated with in vivo tests because published accounts of their chronic toxicity were not available.
测试了八种镰刀菌毒素（单乙酰氧基雪腐镰刀菌烯醇、二乙酰氧基雪腐镰刀菌烯醇、三乙酰氧基雪腐镰刀菌烯醇、T-2毒素、脱氧雪腐镰刀菌烯醇、3-乙酰脱氧雪腐镰刀菌烯醇、玉米赤霉烯酮和串珠镰刀菌素）以及两种阳性对照物（黄曲霉毒素B1和杂色曲霉素）对鼠伤寒沙门氏菌组氨酸需求型菌株TA 98、100、1535和1537的致突变性，测试条件为有和没有代谢激活。黄曲霉毒素B1和杂色曲霉素对鼠伤寒沙门氏菌具有致突变性，但八种镰刀菌毒素均无此作用。T-2毒素和二乙酰氧基雪腐镰刀菌烯醇缺乏致突变活性，这与体内致癌性试验所得出的阴性结果相符。所测试的其他四种12,13-环氧单端孢霉烯族毒素、玉米赤霉烯酮和串珠镰刀菌素的阴性致突变性无法与体内试验相关联，因为未找到有关它们慢性毒性的公开报道。
