多种柄曲霉素相关化合物在肝细胞/DNA修复试验和沙门氏菌微粒体试验中的遗传毒性作用。
Genotoxic effects of a variety of sterigmatocystin-related compounds in the hepatocyte/DNA-repair test and the Salmonella microsome assay.
作者信息
Mori H, Sugie S, Yoshimi N, Kitamura J, Niwa M, Hamasaki T, Kawai K
出版信息
Mutat Res. 1986 Mar;173(3):217-22. doi: 10.1016/0165-7992(86)90039-4.
The genotoxicity and mutagenicity of 11 fungal metabolites structurally related to sterigmatocystin were examined in the hepatocyte primary culture/DNA-repair test and the Salmonella microsome assay. 10 out of the mycotoxins, i.e. dihydrosterigmatocystin, 5-methoxysterigmatocystin, 5-methoxydihydrosterigmatocystin, 5,6-dimethoxysterigmatocystin, 5,6-dimethoxydihydrosterigmatocystin, sterigmatin, O-methylsterigmatocystin and O-acetylsterigmatocystin showed a positive response for DNA repair, suggesting their carcinogenic potency. 5-Methoxysterigmatocystin, 5,6-dimethoxysterigmatocystin demethylsterigmatocystin and O-acetylsterigmatocystin were mutagenic in TA100 of the bacterial mutagenicity assay with liver S9.
在肝细胞原代培养/DNA修复试验和沙门氏菌微粒体试验中，检测了11种与杂色曲霉素结构相关的真菌代谢产物的遗传毒性和致突变性。10种霉菌毒素，即二氢杂色曲霉素、5-甲氧基杂色曲霉素、5-甲氧基二氢杂色曲霉素、5,6-二甲氧基杂色曲霉素、5,6-二甲氧基二氢杂色曲霉素、杂色曲菌素、O-甲基杂色曲霉素和O-乙酰杂色曲霉素对DNA修复呈阳性反应，表明它们具有致癌潜力。5-甲氧基杂色曲霉素、5,6-二甲氧基杂色曲霉素、去甲基杂色曲霉素和O-乙酰杂色曲霉素在有肝脏S9的细菌致突变性试验的TA100中具有致突变性。
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