Rojas Perez-Ezquerra Patricia, Torrado-Español Ines, Tejero-Alcalde Melina, Cuevas-Bravo Cristina, Noguerado-Mellado Blanca
Allergy, Hospital General Universitario Gregorio Marañon, Madrid, ESP.
Cureus. 2021 Oct 22;13(10):e18961. doi: 10.7759/cureus.18961. eCollection 2021 Oct.
Reactions caused by photosensitivity, also called photodermatosis, are cutaneous reactions induced or exacerbated by exposure to electromagnetic radiation, including UV radiation, visible light, and infrared radiation. We present the case of a 41-year-old man with no personal history of allergy and who is referred to our Drug Allergy Unit for study. We performed a conventional patch test (non-irradiated) and photopatch (with the application of UVA) with reading at 48 and 96 hours and 24 hours after irradiation with an intensity of 5J/cm2. Drug-induced photosensitivity can manifest itself in two clinically indistinguishable forms: photoallergy and phototoxicity. Photoallergic reactions are due to an immunological response of type IV hypersensitivity (a cell-mediated mechanism). We present a case of photoallergy due to sensitization to naproxen, confirmed by photopatch tests.
由光敏性引起的反应，也称为光皮肤病，是因暴露于电磁辐射（包括紫外线辐射、可见光和红外线辐射）而诱发或加重的皮肤反应。我们报告了一例41岁男性病例，该患者无个人过敏史，因研究目的被转诊至我们的药物过敏科。我们进行了常规斑贴试验（未照射）和光斑贴试验（应用UVA），分别在48小时和96小时以及在强度为5J/cm2的照射后24小时进行读数。药物性光敏反应可表现为两种临床难以区分的形式：光变应性和光毒性。光变应性反应是由IV型超敏反应（一种细胞介导机制）的免疫反应引起的。我们报告了一例因对萘普生致敏而引起光变应性的病例，光斑贴试验证实了这一点。
