未经治疗的先天性男性化肾上腺皮质增生症中的促性腺激素释放
Gonadotrophin release in untreated congenital virilising adrenal hyperplasia.
作者信息
Pertzelan A, Laron Z, Adler-Bier M, Prager-Lewin R, Kaufman H
出版信息
Arch Dis Child. 1978 Apr;53(4):305-7. doi: 10.1136/adc.53.4.305.
Abstract
A 9.9-year-old boy and a 9.8-year-old girl with virilising congenital adrenal hyperplasia were subjected to an IV LH-RH (luteinising hormone-releasing hormone) test (so microgram/m2 before initition of therapy with corticosteroids. The pattern of response of LH and follicle-stimulating hormone to LH-RH was found to correspond to the stage of their precocious sexual development and advanced bone age, but not to their chronological age. This finding has implications with regard to the mechanism controlling gonadotrophin secretion at puberty.
摘要
一名9.9岁男孩和一名9.8岁女孩患有雄激素化先天性肾上腺增生，在开始使用皮质类固醇治疗前接受了静脉注射促黄体生成素释放激素（LH-RH）测试（剂量为每平方米体重微克）。结果发现，促黄体生成素（LH）和促卵泡生成素（FSH）对LH-RH的反应模式与他们性早熟的阶段和骨龄提前相符，但与他们的实际年龄不符。这一发现对于青春期促性腺激素分泌的控制机制具有重要意义。
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Gonadotrophin release in untreated congenital virilising adrenal hyperplasia.未经治疗的先天性男性化肾上腺皮质增生症中的促性腺激素释放
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本文引用的文献
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Urinary excretion of gonadotropins in congenital adrenal hyperplasia.先天性肾上腺皮质增生症中促性腺激素的尿排泄情况。
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J Clin Endocrinol Metab. 1973 May;36(5):920-4. doi: 10.1210/jcem-36-5-920.
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Gonadotropin output and response to LRH administration in congenital virilizing adrenal hyperplasia.先天性肾上腺皮质增生症患者促性腺激素的分泌及对促黄体生成素释放激素给药的反应
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Gonadotropin output in congenital adrenal hyperplasia before and after adrenal suppression.先天性肾上腺增生症患者肾上腺抑制前后的促性腺激素分泌情况
J Clin Endocrinol Metab. 1976 Oct;43(4):933-6. doi: 10.1210/jcem-43-4-933.
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