School of Public Health, University of Technology Sydney, Broadway, New South Wales, Australia.
Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia.
J Adolesc Young Adult Oncol. 2022 Jun;11(3):245-251. doi: 10.1089/jayao.2021.0054. Epub 2021 Nov 23.
To highlight the various options available for the management of breast cancer diagnosed during pregnancy by describing the investigations, treatment, and outcomes in relation to these women. This is a narrative review of the literature to describe the issues related to pregnancy and obstetric management in patients with breast cancer. It incorporates a description of six cases of women (aged 29-39 years) with a first-time diagnosis of breast cancer during pregnancy to illustrate a number of issues that need to be considered during different trimesters. Of the six cases, two were diagnosed in each pregnancy trimester. A painless breast mass was the presenting symptom in five cases (83%). In all cases, breast ultrasound was the primary diagnostic imaging procedure. Chest X-ray was performed in 3 (50%) and computed tomography in 2 (33%). A core needle biopsy was performed in all cases, and sentinel lymph node biopsy in 3 (50%) cases. Four women had grade 3 tumor; five had estrogen receptor-positive tumors. Four women had breast surgery during pregnancy. Five women gave birth after the induction of labor and/or cesarean section. In all six cases, a multidisciplinary team was involved in the delivery of health care. Regular breast examinations are needed for all pregnant woman during prenatal visits. Breast ultrasonography should be offered if a breast lump or other symptoms are detected. Breast surgery can be safely performed during all pregnancy trimesters, and some systemic therapeutic agents can be administered safely in the second and third trimesters.
为了突出描述在妊娠期间诊断出的乳腺癌的各种管理选择，探讨了这些女性的检查、治疗和结局。这是对文献的叙述性综述，描述了与乳腺癌患者妊娠和产科管理相关的问题。它结合了六例首次在妊娠期间诊断为乳腺癌的女性病例（年龄 29-39 岁），以说明在不同妊娠期间需要考虑的一些问题。在这六例中，每例在妊娠的三个阶段均有诊断。五例（83%）的首发症状为无痛性乳房肿块。在所有病例中，乳房超声检查均为主要的诊断性影像学检查。胸部 X 线检查在 3 例（50%）中进行，计算机断层扫描在 2 例（33%）中进行。所有病例均进行了空心针活检，其中 3 例（50%）进行了前哨淋巴结活检。4 例女性的肿瘤分级为 3 级；5 例女性的肿瘤雌激素受体阳性。4 例女性在妊娠期间进行了乳房手术。5 例女性在引产和/或剖宫产术后分娩。在所有 6 例中，多学科团队均参与了医疗保健服务。所有孕妇在产前检查期间都需要进行常规乳房检查。如果发现乳房肿块或其他症状，应提供乳房超声检查。乳房手术可在妊娠的所有三个阶段安全进行，某些全身治疗药物可在第二和第三孕期安全使用。
