Angle Orthod. 2022 Mar 1;92(2):180-188. doi: 10.2319/030821-184.1.
To compare the rate of extraction space closure between periodontally accelerated osteogenic orthodontics (PAOO) using platelet-rich fibrin (PRF) (Group 1) and PAOO using demineralized bone xenograft (DMBM) (Group 2) and to compare the level of wound healing between the PRF group vs the DMBM group after PAOO.
A two-arm prospective single blind pilot study with a split-mouth design was used in which 14 patients requiring premolar extraction were divided into two groups: PRF and DMBM. En-masse space closure was carried out with using mini implants after the PAOO procedure. The amount of space closure was measured at five time points with 2-week intervals within 2 months. The gingival healing levels were assessed using early wound healing scores on the first postoperative day.
The rate of extraction space closure was faster in the experimental quadrant at all time points (T1-T4) in the PRF group and at time points (T3, T4) in the DMBM group. Comparison between experimental quadrants showed a significant increase in the rate of space closure in the PRF group T1 to T3 (P < .05). The PRF group showed higher total early healing scores than the DMBM group.
PRF, when used in the PAOO procedure, produces a faster rate of space closure with better early wound healing than DMBM.
比较富血小板纤维蛋白（PRF）（第 1 组）和脱矿骨异种移植物（DMBM）（第 2 组）在牙周加速成骨正畸（PAOO）中拔牙间隙关闭率，并比较 PAOO 后 PRF 组与 DMBM 组之间的伤口愈合水平。
采用双臂前瞻性单盲试点研究，采用分口设计，将 14 名需要前磨牙拔牙的患者分为两组：PRF 和 DMBM。在 PAOO 手术后使用微型种植体进行整体间隙关闭。在 2 个月内的 2 周间隔内，在 5 个时间点测量间隙关闭量。在术后第 1 天使用早期伤口愈合评分评估牙龈愈合水平。
在 PRF 组的所有时间点（T1-T4）和 DMBM 组的时间点（T3、T4），实验象限的拔牙间隙关闭率更快。实验象限之间的比较显示，PRF 组 T1 至 T3 时的间隙关闭率显著增加（P <.05）。PRF 组的总早期愈合评分高于 DMBM 组。
在 PAOO 手术中使用 PRF 可产生更快的间隙关闭率，并具有比 DMBM 更好的早期伤口愈合。
