Liu H, Song L, Qi Z, Meng D, Wang J, Lyu Y J, Jia H X, Ding L, Hao M, Tian Z Q, Wang J T
Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
Department of Obstetrics and Gynecology, Second Hospital, Shanxi Medical University, Taiyuan 030001, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Jun 10;42(6):1097-1102. doi: 10.3760/cma.j.cn112338-20200807-01040.
To explore the effect of dietary water-soluble vitamins on the poor prognosis of low-grade cervical intraepithelial neoplasia (CINⅠ). A total of 564 participants with CINⅠ were selected from a community-based married women cohort established in 2014. The general baseline information was collected, and HPV genotyping was detected. A food frequency questionnaire was used to investigate dietary water-soluble vitamins' consumption and determine their exposure levels. The follow-up program was carried out for 12 months, and the regression, persistence, and progression of CINⅠ was determined according to histopathological results at 12-month. The low-levels of dietary water-soluble vitamins could promote CINⅠ's persistence and progression, showing the increasing tendency of CINⅠ poor prognosis with the decrease of water-soluble vitamin levels. Especially folate, VB1, VB2, VB6, niacin, biotin, and VC ( values were 15.22, 1.86, 1.92, 2.11, 2.98, 2.14, 2.19, respectively) played an important role. Considering the status of high-risk human papillomavirus (HR-HPV) infection, our results showed that the low levels of folate, niacin, biotin could promote the poor prognosis of CINⅠ. The low-level of dietary water-soluble vitamins could facilitate the poor prognosis of CINⅠ. In addition, folate, niacin, biotin were more effective on HR-HPV positive women.
探讨膳食水溶性维生素对低级别宫颈上皮内瘤变（CINⅠ）预后不良的影响。从2014年建立的社区已婚女性队列中选取了564例CINⅠ参与者。收集一般基线信息，并检测HPV基因分型。使用食物频率问卷调查膳食水溶性维生素的摄入量并确定其暴露水平。进行了12个月的随访计划，并根据12个月时的组织病理学结果确定CINⅠ的消退、持续和进展情况。膳食水溶性维生素水平低可促进CINⅠ的持续和进展，显示出随着水溶性维生素水平降低CINⅠ预后不良的趋势增加。尤其是叶酸、VB1、VB2、VB6、烟酸、生物素和VC（值分别为15.22、1.86、1.92、2.11、2.98、2.14、2.19）发挥了重要作用。考虑到高危人乳头瘤病毒（HR-HPV）感染状况，我们的结果表明叶酸、烟酸、生物素水平低可促进CINⅠ的预后不良。膳食水溶性维生素水平低可促使CINⅠ预后不良。此外，叶酸、烟酸、生物素对HR-HPV阳性女性更有效。
