Xi Y E, Gao W J, Lyu J, Yu C Q, Wang S F, Huang T, Sun D J Y, Liao C X, Pang Z C, Yu M, Wang H, Wu X P, Dong Z, Wu F, Jiang G H, Wang X J, Liu Y, Deng J, Lu L, Cao W H, Li L M
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Sep 10;42(9):1573-1579. doi: 10.3760/cma.j.cn112338-20201130-01362.
To explore the gene-body mass index (BMI) interaction on coronary heart disease (CHD) in the Chinese adult twins. A total of 20 340 same-sex twin pairs registered in the Chinese National Twin Registry (CNTR) were enrolled in this study. Classical twin structure equation model was used to estimate the gene-BMI interaction on CHD. After adjusting for age, we found that genetic variance of CHD differed as the function of BMI in male twins, which indicated the presence of a gene-BMI interaction on CHD (=0.008).The genetic moderating effect () was -0.14 (95%: -0.22--0.04), indicating that for each logarithmic transformation value of BMI increase, genetic path parameters would decrease by 0.14, which would result in the decrease of genetic variance of CHD. And the heritability of CHD was 0.77 (95%: 0.65-0.86) among the male twins with lower BMI (<24.0 kg/m), but 0.56 (95%: 0.33-0.74) among the male twins with high BMI (≥24.0 kg/m). However, there was no evidence suggesting that BMI could moderate genetic variants of CHD in female. We found a significant gene-BMI interaction on CHD in the Chinese male adult twins in China, and the heritability of CHD was higher among the twins whose BMI was <24.0 kg/m.
探索中国成年双胞胎中基因与体重指数（BMI）对冠心病（CHD）的相互作用。本研究纳入了中国国家双胞胎登记处（CNTR）登记的总共20340对同性双胞胎。采用经典双胞胎结构方程模型来估计基因 - BMI对冠心病的相互作用。在调整年龄后，我们发现男性双胞胎中冠心病的遗传方差随BMI的变化而不同，这表明存在基因 - BMI对冠心病的相互作用（=0.008）。遗传调节效应（）为 -0.14（95%置信区间：-0.22--0.04），这表明BMI每增加一个对数转换值，遗传路径参数将降低0.14，这将导致冠心病遗传方差的降低。在BMI较低（<24.0 kg/m）的男性双胞胎中，冠心病的遗传度为0.77（95%置信区间：0.65 - 0.86），而在BMI较高（≥24.0 kg/m）的男性双胞胎中，遗传度为0.56（95%置信区间：0.33 - 0.74）。然而，没有证据表明BMI能调节女性冠心病的遗传变异。我们在中国成年男性双胞胎中发现了基因 - BMI对冠心病的显著相互作用，且在BMI<24.0 kg/m的双胞胎中冠心病的遗传度更高。
