Xi Y E, Gao W J, Lyu J, Yu C Q, Wang S F, Huang T, Sun D J Y, Liao C X, Pang Y J, Pang Z C, Yu M, Wang H, Wu X P, Dong Z, Wu F, Jiang G H, Wang X J, Liu Y, Deng J, Lu L, Cao W H, Li Liming
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2022 May 10;43(5):649-654. doi: 10.3760/cma.j.cn112338-20210707-00530.
To explore the gene-lifestyle interaction on coronary heart disease (CHD) in adult twins of China. Participants were selected from twin pairs registered in the Chinese National Twin Registry (CNTR). Univariate interaction model was used to estimate the interaction, via exploring the moderation effect of lifestyle on the genetic variance of CHD. A total of 20 477 same-sex twin pairs aged ≥25 years were recruited, including 395 CHD cases, and 66 twin pairs both had CHD. After adjustment for age and sex, no moderation effects of lifestyles, including current smoking, current drinking, physical activity, intake of vegetable and fruit, on the genetic variance of CHD were found (>0.05), suggesting no significant interactions. There was no evidence suggesting statistically significant gene-lifestyle interaction on CHD in adult twins of China.
为探讨中国成年双胞胎中基因与生活方式对冠心病（CHD）的相互作用。研究对象选自中国国家双胞胎登记处（CNTR）登记的双胞胎对。通过探索生活方式对冠心病遗传方差的调节作用，采用单变量相互作用模型来估计相互作用。共招募了20477对年龄≥25岁的同性双胞胎对，其中包括395例冠心病病例，66对双胞胎均患有冠心病。在对年龄和性别进行调整后，未发现包括当前吸烟、当前饮酒、身体活动、蔬菜和水果摄入量在内的生活方式对冠心病遗传方差有调节作用（>0.05），表明无显著相互作用。没有证据表明中国成年双胞胎中基因与生活方式对冠心病存在统计学上的显著相互作用。
