Xi Y E, Gao W J, Hong X M, Lyu J, Yu C Q, Wang S F, Huang T, Sun D J Y, Liao C X, Pang Y J, Pang Z C, Yu M, Wang H, Wu X P, Dong Z, Wu F, Jiang G H, Wang X J, Liu Y, Deng J, Lu L, Cao W H, Li Liming
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2022 Jul 6;56(7):940-946. doi: 10.3760/cma.j.cn112150-20210707-00651.
To examine the heritability of body mass index (BMI) and coronary heart disease (CHD), and to explore whether genetic factors can explain their correlation. Participants were from 11 provinces/municipalities reqistered in the Chinese National Twin Registry (CNTR) from 2010 to 2018. Participants data were collected from face-to-face questionnaire survey. Bivariate structure equation model was used to estimate the heritability and the genetic correlation of BMI and CHD. A total of 20 340 pairs of same-sex twins aged ≥25 years were included in this study. After adjusting for age and gender, the heritability of BMI and CHD was 0.52 (95%: 0.49-0.55) and 0.76 (95%: 0.69-0.81), respectively. Further, a genetic correlation was identified between BMI and CHD (=0.10, 95%:0.02-0.17). In Chinese adult twin population, BMI and CHD are affected by genetic factors, and their correlation can be attributed to the common genetic basis.
为了研究体重指数（BMI）和冠心病（CHD）的遗传性，并探讨遗传因素是否可以解释它们之间的相关性。参与者来自2010年至2018年在中国国家双胞胎登记处（CNTR）登记的11个省/直辖市。参与者的数据通过面对面问卷调查收集。采用双变量结构方程模型来估计BMI和CHD的遗传性以及遗传相关性。本研究共纳入了20340对年龄≥25岁的同性双胞胎。在调整年龄和性别后，BMI和CHD的遗传性分别为0.52（95%：0.49 - 0.55）和0.76（95%：0.69 - 0.81）。此外，还确定了BMI和CHD之间的遗传相关性（=0.10，95%：0.02 - 0.17）。在中国成年双胞胎人群中，BMI和CHD受遗传因素影响，它们之间的相关性可归因于共同的遗传基础。
