Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA; Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA; Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Semin Immunol. 2021 Mar;53:101529. doi: 10.1016/j.smim.2021.101529. Epub 2021 Nov 21.
It has been appreciated that basophilia is a common feature of helminth infections for approximately 50 years. The ability of basophils to secrete IL-4 and other type 2 cytokines has supported the prevailing notion that basophils contribute to antihelminth immunity by promoting optimal type 2 T helper (Th2) cell responses. While this appears to be the case in several helminth infections, emerging studies are also revealing that the effector functions of basophils are extremely diverse and parasite-specific. Further, new reports now suggest that basophils can restrict type 2 inflammation in a manner that preserves the integrity of helminth-affected tissue. Finally, exciting data has also demonstrated that basophils can regulate inflammation by participating in neuro-immune interactions. This article will review the current state of basophil biology and describe how recent studies are transforming our understanding of the role basophils play in the context of helminth infections.
大约 50 年来，人们已经认识到嗜碱性粒细胞是寄生虫感染的一个常见特征。嗜碱性粒细胞能够分泌 IL-4 和其他 2 型细胞因子，这支持了这样一种流行观点，即嗜碱性粒细胞通过促进最佳的 2 型辅助性 T 细胞（Th2）细胞反应来有助于抗寄生虫免疫。虽然这在几种寄生虫感染中似乎是如此，但新的研究也表明，嗜碱性粒细胞的效应功能极其多样化且具有寄生虫特异性。此外，新的报告现在表明，嗜碱性粒细胞可以以一种保留受寄生虫影响组织完整性的方式限制 2 型炎症。最后，令人兴奋的数据还表明，嗜碱性粒细胞可以通过参与神经免疫相互作用来调节炎症。本文将综述嗜碱性粒细胞生物学的现状，并描述最近的研究如何改变我们对嗜碱性粒细胞在寄生虫感染背景下所起作用的理解。
