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接触者追踪在减轻新冠病毒传播方面的效率如何?一种数学建模方法。

How efficient is contact tracing in mitigating the spread of COVID-19? a mathematical modeling approach.

作者信息

Biala T A, Afolabi Y O, Khaliq A Q M

机构信息

Department of Mathematics, The Ohio State University, USA.

Department of Mathematics, University of Louisiana at Lafayette, USA.

出版信息

Appl Math Model. 2022 Mar;103:714-730. doi: 10.1016/j.apm.2021.11.011. Epub 2021 Nov 19.

Abstract

Contact Tracing (CT) is one of the measures taken by government and health officials to reduce the spread of the novel coronavirus. In this paper, we investigate its efficacy by developing a compartmental model for assessing its impact on mitigating the spread of the virus. We describe the impact on the reproduction number of COVID-19. In particular, we discuss the importance and relevance of parameters of the model such as the number of reported cases, effectiveness of tracking and monitoring policy, and the transmission rates to contact tracing. We describe the terms "perfect tracking", "perfect monitoring" and "perfect reporting" to indicate that traced contacts will be tracked while incubating, tracked contacts are efficiently monitored so that they do not cause secondary infections, and all infected persons are reported, respectively. We consider three special scenarios: (1) perfect monitoring and perfect tracking of contacts of a reported case, (2) perfect reporting of cases and perfect monitoring of tracked reported cases and (3) perfect reporting and perfect tracking of contacts of reported cases. Furthermore, we gave a lower bound on the proportion of contacts to be traced to ensure that the effective reproduction, , is below one and describe in terms of observable quantities such as the proportion of reported and traced cases. Model simulations using the COVID-19 data obtained from John Hopkins University for some selected states in the US suggest that even late intervention of CT may reasonably reduce the transmission of COVID-19 and reduce peak hospitalizations and deaths. In particular, our findings suggest that effective monitoring policy of tracked cases and tracking of traced contacts while incubating are more crucial than tracing more contacts. The use of CT coupled with other measures such as social distancing, use of face mask, self-isolation or quarantine and lockdowns will greatly reduce the spread of the epidemic as well as peak hospitalizations and total deaths.

摘要

接触者追踪(CT)是政府和卫生官员为减少新型冠状病毒传播而采取的措施之一。在本文中,我们通过开发一个分区模型来评估其对减轻病毒传播的影响,从而研究其有效性。我们描述了对COVID-19基本再生数的影响。特别是,我们讨论了模型参数的重要性和相关性,如报告病例数、追踪和监测政策的有效性以及接触者追踪的传播率。我们描述了“完美追踪”“完美监测”和“完美报告”这几个术语,分别表示追踪到的接触者在潜伏期将被追踪、被追踪的接触者得到有效监测从而不会引起二次感染以及所有感染者都被报告。我们考虑三种特殊情况:(1)对报告病例的接触者进行完美监测和完美追踪;(2)对病例进行完美报告以及对被追踪的报告病例进行完美监测;(3)对报告病例的接触者进行完美报告和完美追踪。此外,我们给出了为确保有效再生数(R_e)低于1而需要追踪的接触者比例的下限,并根据可观察量(如报告病例和追踪病例的比例)来描述(R_e)。使用从美国约翰·霍普金斯大学获得的一些选定州的COVID-19数据进行的模型模拟表明,即使接触者追踪的干预较晚,也可能合理地减少COVID-19的传播,并减少住院和死亡高峰。特别是,我们的研究结果表明,对被追踪病例的有效监测政策以及在潜伏期对被追踪接触者的追踪比追踪更多接触者更为关键。将接触者追踪与其他措施(如保持社交距离、佩戴口罩、自我隔离或检疫以及封锁)相结合,将大大减少疫情的传播以及住院高峰和总死亡人数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b3e/8603240/2122c4ae60db/gr1_lrg.jpg

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