Emanoil Alina-Raluca, Stochino Loi Emanuela, Feki Anis, Ben Ali Nordine
Department of Gynecology and Obstetrics, Fribourg Cantonal Hospital, Fribourg, Switzerland.
Front Glob Womens Health. 2021 Oct 11;2:590945. doi: 10.3389/fgwh.2021.590945. eCollection 2021.
Since the emergence of a novel coronavirus in China at the end of December 2019, its infection - COVID-19 - has been associated with high morbidity and mortality and has left healthcare systems wrestling with the optimal management strategy, especially for vulnerable populations, such as pregnant women. At this moment, few resources exist to guide the multi-disciplinary team through decisions regarding optimal maternal-fetal treatment and delivery timing. In this article, we present the drugs and vaccines under investigation as potential treatments and prevention for COVID-19 infection. Based on a comprehensive evaluation, we prioritized these possible treatments, and provide dose-response and dose-toxicity information on each drug. Currently, there is limited but very increasing reassuring information concerning vaccines to prevent SARS-CoV-2 during pregnancy, and in this review, we also emphasize the results (mostly positive) provided by the few small trials evaluating COVID-19 vaccines in pregnant patients.
自2019年12月底中国出现新型冠状病毒以来，其引发的感染——新冠肺炎——已导致高发病率和高死亡率，给医疗系统带来挑战，使其难以应对最佳管理策略，尤其是针对孕妇等弱势群体。目前，几乎没有资源可指导多学科团队做出关于最佳母婴治疗和分娩时机的决策。在本文中，我们介绍了正在研究的作为新冠肺炎感染潜在治疗和预防手段的药物和疫苗。基于全面评估，我们对这些可能的治疗方法进行了排序，并提供了每种药物的剂量反应和剂量毒性信息。目前，关于孕期预防新冠病毒的疫苗的信息有限，但越来越令人安心，在本综述中，我们还强调了少数评估孕妇接种新冠肺炎疫苗的小型试验所提供的结果（大多为阳性）。
