长链非编码 RNA SNHG3 通过与 YAP1 结合促进宫颈癌细胞的恶性表型。
Long noncoding RNA SNHG3 promotes malignant phenotypes in cervical cancer cells via association with YAP1.
机构信息
Gynecology Second Ward, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, 443003, Hubei, China.
Gastrointestinal Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, 443003, Hubei, China.
出版信息
Hum Cell. 2022 Jan;35(1):320-332. doi: 10.1007/s13577-021-00644-7. Epub 2021 Nov 24.
Long non-coding RNA (LncRNA) Small Nucleolar RNA Host Gene 3 (SNHG3) is involved in the occurrence and development of various cancers. However, the exact function and mechanism of SNHG3 in cervical cancer (CC) are still unclear. In this context, we identified a significant increase of SNHG3 expression in CC tissues. Upregulation of SNHG3 expression was associated with advanced FIGO stage and metastasis, and indicated poor overall survival of the CC patients. Functionally, SNHG3 enhanced the proliferation, migration and invasion of CC cells in vitro, and facilitated CC growth in vivo. Further investigation uncovered that SNHG3 interacted with oncoprotein YAP1, thus suppressing its degradation. Additionally, SNHG3 modulated the transcription of several target genes of YAP1. The oncogenic role of SNHG3 was partially attributable to YAP1. Taken together, our research revealed the prognostic and functional roles for SNHG3 in CC, suggesting that SNHG3 could serve as a biomarker for prognosis and a therapeutic target for CC.
长链非编码 RNA（LncRNA）小核仁 RNA 宿主基因 3（SNHG3）参与各种癌症的发生和发展。然而，SNHG3 在宫颈癌（CC）中的确切功能和机制仍不清楚。在这方面，我们发现 SNHG3 在 CC 组织中的表达显著增加。SNHG3 表达的上调与 FIGO 晚期和转移有关，并表明 CC 患者的总体生存率较差。功能上，SNHG3 增强了 CC 细胞在体外的增殖、迁移和侵袭能力，并促进了 CC 的体内生长。进一步的研究揭示了 SNHG3 与癌蛋白 YAP1 相互作用，从而抑制其降解。此外，SNHG3 调节了 YAP1 的几个靶基因的转录。SNHG3 的致癌作用部分归因于 YAP1。总之，我们的研究揭示了 SNHG3 在 CC 中的预后和功能作用，表明 SNHG3 可以作为 CC 的预后标志物和治疗靶点。
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