城市环境中接受内分泌治疗的乳腺癌患者与癌症相关疲劳相关的因素：一项横断面研究。
Factors associated with cancer-related fatigue in breast cancer patients undergoing endocrine therapy in an urban setting: a cross-sectional study.
机构信息
Department of Medical Oncology, Tumor Hospital of Harbin Medical University, Harbin, China.
出版信息
BMC Cancer. 2010 Aug 23;10:453. doi: 10.1186/1471-2407-10-453.
BACKGROUND
Fatigue is prevalent in breast cancer survivors and has profound effects on daily life. The interference of fatigue with endocrine therapy may be difficult to separate. This study investigates the prevalence and severity of fatigue and identifies the demographic, clinical, and lifestyle factors associated with cancer-related fatigue (CRF) in breast cancer patients undergoing endocrine therapy in an urban area.
METHODS
Women with stage I-IIIA breast cancer were recruited and asked to participate (n = 371) in the study. The 315 women who responded to the questionnaire (84.9%), 54 (17.1%) had completed endocrine therapy and 261 (82.9%) were still undergoing endocrine therapy. The patients had been diagnosed at an average of 31 months prior to recruitment (range, 7 to 60 months); the average age was 48 (range, 33 to 72) years. The 11-point scale and Visual Analog Scale (VAS) were employed to quantify the level of fatigue experienced by the patients. Logistic regression analyses and a trend test method were performed to evaluate factors associated with CRF.
RESULTS
Among the 315 patients, 189 (60%) had experienced or were experiencing CRF during endocrine therapy. Logistic regression analysis was performed to identify factors associated with CRF, including BMI (body mass index), clinical stage, menopausal status, duration of endocrine therapy, physical activity, and diet. Factors unrelated to CRF were age, marital status, treatment, endocrine therapy drugs, alcohol intake, and smoking. The trend test method revealed an association between physical activity and dietary level and the intensity of CRF.
CONCLUSIONS
The present findings suggest that fatigue is an important problem in the majority of breast cancer patients during endocrine therapy. We found that BMI, clinical stage, menopausal status, duration of endocrine therapy, physical activity, and diet are associated with fatigue. Future research should focus on the impact factors of CRF and lifestyle in the management of breast cancer patients.
背景
疲劳在乳腺癌幸存者中很常见，对日常生活有深远影响。疲劳对内分泌治疗的干扰可能难以分离。本研究调查了城市地区接受内分泌治疗的乳腺癌患者中癌症相关疲劳（CRF）的患病率和严重程度，并确定了与 CRF 相关的人口统计学、临床和生活方式因素。
方法
招募了 I 期至 IIIA 期乳腺癌患者并邀请他们参加（n=371）。对问卷做出回应的 315 名女性（84.9%）中，54 名（17.1%）已完成内分泌治疗，261 名（82.9%）仍在接受内分泌治疗。患者在招募前平均被诊断出 31 个月（范围 7 至 60 个月）；平均年龄为 48 岁（范围 33 至 72 岁）。11 分制和视觉模拟量表（VAS）用于量化患者的疲劳程度。采用逻辑回归分析和趋势检验方法评估与 CRF 相关的因素。
结果
在 315 名患者中，189 名（60%）在接受内分泌治疗期间经历或正在经历 CRF。进行逻辑回归分析以确定与 CRF 相关的因素，包括 BMI（体重指数）、临床分期、绝经状态、内分泌治疗持续时间、身体活动和饮食。与 CRF 无关的因素包括年龄、婚姻状况、治疗、内分泌治疗药物、饮酒和吸烟。趋势检验方法显示身体活动和饮食水平与 CRF 强度之间存在关联。
结论
本研究结果表明，疲劳是大多数乳腺癌患者在内分泌治疗期间的一个重要问题。我们发现 BMI、临床分期、绝经状态、内分泌治疗持续时间、身体活动和饮食与疲劳有关。未来的研究应侧重于 CRF 的影响因素和生活方式在乳腺癌患者管理中的作用。
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