School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, People's Republic of China.
Org Lett. 2021 Dec 17;23(24):9602-9605. doi: 10.1021/acs.orglett.1c03812. Epub 2021 Nov 24.
Euphohyrisnoids A () and B (), two highly rearranged lathyrane diterpenoids featuring a unique tetracyclo[10.2.2.0.0]cetane and tricyclo[8.4.1.0]pentadecane skeleton, respectively, were isolated from the seeds of . Their structures were determined by detailed spectroscopic analysis and were further confirmed by single-crystal X-ray diffraction. significantly inhibited adipogenesis in 3T3-L1 adipocytes by retarding cell differentiation at the early stage.
Euphohyrisnoids A () 和 B (), 两个高度重排的拉蒂烷二萜类化合物，分别具有独特的四环[10.2.2.0.0]十六烷和三环[8.4.1.0]十五烷骨架，从 Euphorbia lathyris 种子中分离得到。通过详细的光谱分析确定了它们的结构，并通过单晶 X 射线衍射进一步证实。显著抑制 3T3-L1 脂肪细胞中的脂肪生成，通过延迟早期细胞分化。
