Lv Mingchun, Sun Da-Wen, Huang Lunjie, Pu Hongbin
School of Food Science and Engineering, South China University of Technology, Guangzhou, China.
Academy of Contemporary Food Engineering, South China University of Technology, Guangzhou Higher Education Mega Centre, Guangzhou, China.
Crit Rev Food Sci Nutr. 2022;62(15):3991-4009. doi: 10.1080/10408398.2021.2004086. Epub 2021 Nov 24.
Controlled release (CR) systems have become a powerful platform for accurate and effective delivery of bioactive compounds (BCs). Metal-organic frameworks (MOFs) are one of the best BCs-loaded carriers for CR systems. In the review, the principles and methods of the design and synthesis of MOFs-CR systems are summarized in detail, the encapsulation of BCs by MOFs and CR mechanisms are explored, and their biological toxicity and biocompatibility are highlighted and applications in the food industry are discussed. In addition, current challenges in this field and possible future development directions are also presented. MOFs have been proven to encapsulate BCs effectively, including gaseous and solid molecules, and control the release of BCs through spontaneous diffusion or stimulus-response. The solubility, stability and biocompatibility of BCs encapsulated by MOFs are greatly improved, which expands their applications in foods. The effective CR of BCs by MOFs-CR systems is beneficial to assist in maintaining or even improving the quality and safety of food, reduce the BCs usage while increasing the bioavailability. Low- or non-biotoxic MOFs, especially bio-MOFs, show greater application prospects in the food industry.
控释（CR）系统已成为准确、有效递送生物活性化合物（BCs）的强大平台。金属有机框架（MOFs）是用于CR系统的最佳载有BCs的载体之一。在本综述中，详细总结了MOFs-CR系统设计与合成的原理和方法，探讨了MOFs对BCs的包封及CR机制，强调了它们的生物毒性和生物相容性，并讨论了其在食品工业中的应用。此外，还介绍了该领域当前面临的挑战以及未来可能的发展方向。已证明MOFs能有效包封BCs，包括气态和固态分子，并通过自发扩散或刺激响应来控制BCs的释放。MOFs包封的BCs的溶解度、稳定性和生物相容性得到极大提高，这扩大了它们在食品中的应用。MOFs-CR系统对BCs的有效控释有助于维持甚至提高食品的质量和安全性，在减少BCs用量的同时提高其生物利用度。低生物毒性或无生物毒性的MOFs，尤其是生物MOFs，在食品工业中显示出更大的应用前景。
