Institute of Home and Food Sciences, Faculty of Life Science, Government College University, Faisalabad, Pakistan.
Department of Chemistry, Faculty of Sciences, Government College University, Faisalabad.
Cell Mol Biol (Noisy-le-grand). 2021 Jan 31;67(1):132-141. doi: 10.14715/cmb/2021.67.1.20.
The Current study was planned to explore the therapeutic potential of green tea, black tea and ginger based nutraceuticals (catechins, theaflavins and ginger freeze dried extract) against obesity, diabetes and renal malfunctioning. Bioevaluation study was carried out by involving 250 male Sprague Dawley rats. Accordingly, three types of studies were conducted on the basis of different diets i.e. study I (Hyperglycemic rats), study II (obese rats), study III (liver malfunctional rats) each study comprised of five groups of rats ten in each (Sample size according to power analysis) were provided the five types of drinks i.e. control, theaflavin enriched, catechins enriched, ginger extract supplemented and combination of catechins, theaflavins and ginger extract were given to the representative groups. Results showed that the body weight of rats effected significantly with functional drinks in all studies. However, catechin enriched drink (T1) resulted maximum reduction in weight during the entire study. Similarly, T2 exerted maximum decline in cholesterol level during study I, II and III by 11.03 & 10.63, 7.62 & 8.05 and 5.99 & 6.01% whereas LDL by 14.25 & 15.10, 10.45 & 12.10 and 7.25 & 8.01%, respectively (trial 1 & 2). The attenuation in serum glucose and enhancement in insulin level of rats are the indicators for the positive impact of black tea functional drinks. In this context, Catechins+theaflavins+GFD enriched drink (T4) Showed better performance than rest and caused 8.82 & 9.77, 11.03 & 12.23 and 5.83 & 5.96% reduction in glucose. Moreover, the T4 significantly improved the liver and antioxidant enzymes. Accordingly, T4 was proved effective for glutathione enhancement whilst T2 alleviated TBARS efficiently during the investigation. The normal ranges of renal function tests and hematological aspects proved the safety of resultant drinks. From the current exploration, it is concluded that drinks supplemented with theaflavin and catechins & GFD are effectual to mitigate lifestyle related malfunctioning.
本研究旨在探索绿茶、红茶和姜类营养保健品（儿茶素、茶黄素和姜冻干提取物）对肥胖、糖尿病和肾功能障碍的治疗潜力。通过涉及 250 只雄性 Sprague Dawley 大鼠进行了生物评价研究。因此，根据不同的饮食进行了三种类型的研究，即研究 I（高血糖大鼠）、研究 II（肥胖大鼠）和研究 III（肝功能障碍大鼠），每个研究包括五组大鼠，每组 10 只（根据功效分析确定样本量），分别给予五种类型的饮料，即对照、茶黄素富集、儿茶素富集、姜提取物补充和儿茶素、茶黄素和姜提取物的组合。结果表明，在所有研究中，功能性饮料对大鼠体重有显著影响。然而，儿茶素富集饮料（T1）在整个研究过程中体重减轻最多。同样，T2 在研究 I、II 和 III 中使胆固醇水平分别下降 11.03%、10.63%、7.62%和 8.05%、5.99%和 6.01%，LDL 分别下降 14.25%、15.10%、10.45%和 12.10%、7.25%和 8.01%（试验 1 和 2）。大鼠血清葡萄糖的降低和胰岛素水平的升高是红茶功能性饮料产生积极影响的指标。在这方面，儿茶素+茶黄素+GFD 富集饮料（T4）的表现优于其他，使葡萄糖降低 8.82%、9.77%、11.03%和 12.23%、5.83%和 5.96%。此外，T4 显著改善了肝脏和抗氧化酶。因此，T4 被证明能有效增强谷胱甘肽，而 T2 在研究过程中能有效缓解 TBARS。肾功能试验和血液学方面的正常范围证明了所得饮料的安全性。从目前的探索来看，补充茶黄素和儿茶素和 GFD 的饮料对减轻与生活方式相关的功能障碍是有效的。
