Ziyanok-Demirtas Sedef
Department of Biology, Faculty of Science and Arts, Bursa Uludag University, Bursa 16059, Turkey.
Life (Basel). 2024 May 27;14(6):686. doi: 10.3390/life14060686.
Diabetes mellitus (DM) is a significant global health burden that necessitates the exploration of effective and accessible therapeutic options. Phytotherapy has played a vital role in healthcare, with plant extracts being integral to traditional medicinal practices. The therapeutic potential of (Rose of Sharon), a plant with a rich ethnobotanical history, in the management of DM and its associated complications was investigated. In this study, the therapeutic potential of L. extract (HSE) against DM in streptozotocin (STZ)-induced diabetic rats was assessed, focusing on its effects on glucose regulation, antioxidative defense, and liver protection. The administration of the HSE extract substantially reduced hyperglycemia and increased insulin production, with concurrent improvements in body weight and hydration. The enhanced activity of antioxidant enzymes, such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), suggests reduced oxidative stress, which is further supported by molecular docking results with the 3GTV superoxide dismutase enzyme, showing a binding energy of -6.3 kcal/mol. A decrease in MDA levels also indicates a reduction in oxidative stress. Notably, HSE treatment led to decreased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and improved lipid profiles, indicating its hepatoprotective and lipid-modifying benefits. These findings support the inclusion of HSE as an adjunctive therapy in DM management strategies. This study promotes the consideration of L. therapeutic properties in global health contexts.
糖尿病（DM）是一项重大的全球健康负担，这就需要探索有效且可及的治疗方案。植物疗法在医疗保健中发挥了重要作用，植物提取物是传统医学实践的重要组成部分。人们对锦葵（有着丰富民族植物学历史的一种植物）在糖尿病及其相关并发症管理方面的治疗潜力进行了研究。在本研究中，评估了锦葵提取物（HSE）对链脲佐菌素（STZ）诱导的糖尿病大鼠的抗糖尿病治疗潜力，重点关注其对血糖调节、抗氧化防御和肝脏保护的作用。给予HSE提取物可显著降低高血糖并增加胰岛素分泌，同时体重和水合作用也有所改善。抗氧化酶如超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）活性增强，表明氧化应激降低，这进一步得到了与3GTV超氧化物歧化酶分子对接结果的支持，显示结合能为-6.3千卡/摩尔。丙二醛（MDA）水平降低也表明氧化应激减少。值得注意的是，HSE治疗导致天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）水平降低，并改善了血脂谱，表明其具有肝脏保护和脂质调节益处。这些发现支持将HSE纳入糖尿病管理策略中的辅助治疗。本研究促使人们在全球健康背景下考虑锦葵的治疗特性。
