COVID-19 住院患者的情绪反应障碍：来自单中心队列的经验。
Mood Reactive Disorders among COVID-19 Inpatients: Experience from a Monocentric Cohort.
机构信息
Infectious and Tropical Diseases Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Psychiatric Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
出版信息
Med Princ Pract. 2021;30(6):535-541. doi: 10.1159/000518490. Epub 2021 Sep 28.
OBJECTIVE
We aimed to investigate the presence and severity of depressive symptoms among coronavirus disease 2019 (COVID-19) inpatients and any possible changes after their discharge.
SUBJECT AND METHODS
We collected data of patients admitted to the Infectious Disease Unit in Sassari, Italy, for COVID-19, from March 8 to May 8, 2020. The Beck Depression Inventory-II (BDI-II) was performed 1 week after admission (T0) and 1 week after discharge (T1). The cutoff point chosen to define the clinical significance of depressive symptoms was 20 (at least moderate).
RESULTS
Forty-eight subjects were included. Mean age was 64.3 ± 17.6 years, and 32 (66.7%) were male. Most frequent comorbidities were cardiovascular diseases (19; 39.6%) and hypertension (17; 35.4%). When performing BDI-II at T0, 21 (43.7%) patients reported depressive symptoms at T0, according to the chosen cutoff point (BDI-II = 20). Eight (16.7%) patients had minimal symptoms. Mild mood disturbance and moderate and severe depressive symptoms were found in 24 (50%), 14 (29.2%), and 2 (4.2%) patients, respectively, at T0. The comparison of the BDI-II questionnaire at T0 with T1 showed a significant improvement in the total score (p < 0.0001), as well as in 4 out of the 5 selected questions of interest (p < 0.05). Univariate analysis showed that kidney failure and the death of a roommate were significantly associated with severity of mood disorders.
CONCLUSION
Mood disturbances and depressive symptoms commonly occur among COVID-19 inpatients. Our results show that COVID-19 inpatients might be at higher risk for developing depressive reactive disorders and could benefit from an early psychological evaluation and strategies improving sleep quality.
目的
我们旨在调查 2019 年冠状病毒病（COVID-19）住院患者中抑郁症状的存在和严重程度，以及出院后的任何可能变化。
方法
我们收集了 2020 年 3 月 8 日至 5 月 8 日期间在意大利萨萨里传染病科住院的 COVID-19 患者的数据。在入院后 1 周（T0）和出院后 1 周（T1）进行贝克抑郁量表第二版（BDI-II）。选择 20 作为定义抑郁症状临床意义的临界值（至少为中度）。
结果
共纳入 48 例患者。平均年龄为 64.3 ± 17.6 岁，32 例（66.7%）为男性。最常见的合并症是心血管疾病（19 例；39.6%）和高血压（17 例；35.4%）。根据所选临界值（BDI-II = 20），在 T0 进行 BDI-II 时，21 例（43.7%）患者报告存在抑郁症状。8 例（16.7%）患者仅有轻微症状。T0 时，24 例（50%）患者存在轻度情绪障碍，14 例（29.2%）患者存在中度和重度抑郁症状，2 例（4.2%）患者存在严重抑郁症状。T0 和 T1 时 BDI-II 问卷的比较显示总分显著改善（p < 0.0001），以及 5 个感兴趣问题中的 4 个问题的得分显著改善（p < 0.05）。单因素分析显示，肾衰竭和室友死亡与情绪障碍严重程度显著相关。
结论
情绪障碍和抑郁症状在 COVID-19 住院患者中常见。我们的结果表明，COVID-19 住院患者可能面临更高的发展抑郁反应性障碍的风险，并可能受益于早期心理评估和改善睡眠质量的策略。
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