School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China.
Department of Organic Chemistry, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
Food Chem. 2022 Mar 15;372:131335. doi: 10.1016/j.foodchem.2021.131335. Epub 2021 Oct 5.
Mulberry leaves (MLs) have been used traditionally to raise silkworms and as herbs and herbal drinks. In vitro and in vivo studies as well as some clinical trials provide some evidence of health benefits, mostly for ML extracts. ML extracts showed antioxidant, hypoglycemic, anticholesterol (affecting lipid metabolism), antiobesity, anti-inflammatory, anticancer activities, and so on. These might be linked to strong antioxidant activities, inhibition of α-glucosidase and α-amylase, reduction of foam cell formation, inhibition of fat formation, decrease of NF-κB activity, and the promotion or induction of apoptosis. Phenolic constituents, especially flavonoids, phenolic acids and alkaloids, are likely to contribute to the reported effects. The phytochemistry and pharmacology of MLs confer the traditional and current uses as medicine, food, fodder, and cosmetics. This paper reviews the economic value, chemical composition and pharmacology of MLs to provide a reference for the development and utilization of MLs.
桑叶（Mulberry leaves，MLs）自古以来一直被用于养蚕、入药和制作草药茶。体外和体内研究以及一些临床试验提供了一些健康益处的证据，主要针对 ML 提取物。ML 提取物具有抗氧化、降血糖、抗胆固醇（影响脂质代谢）、抗肥胖、抗炎、抗癌等活性。这些可能与强大的抗氧化活性、抑制 α-葡萄糖苷酶和 α-淀粉酶、减少泡沫细胞形成、抑制脂肪形成、降低 NF-κB 活性以及促进或诱导细胞凋亡有关。酚类成分，尤其是类黄酮、酚酸和生物碱，可能有助于解释报道的这些作用。MLs 的植物化学和药理学赋予了其作为药物、食品、饲料和化妆品的传统和现代用途。本文综述了 MLs 的经济价值、化学成分和药理学，为 MLs 的开发利用提供了参考。
