Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.
Molecules. 2024 Aug 23;29(17):3981. doi: 10.3390/molecules29173981.
L. is a tradition medical and edible plant. It is rich in many important bioactive components. However, there is a dearth of systematic information about the components. Here, the Mori Cortex, Mori Folium, Mori Fructus, and Mori Ramulus were studied. Ultrahigh-performance liquid chromatography-mass spectrometry (UHPLC-MS) is used to study primary and secondary metabolites. Eight hundred two metabolites were identified and classified into 10 different categories in total. Correlation analysis, hierarchical clustering analysis, and principal component analysis of metabolites showed that different parts of the sample could be significantly different. In different medicinal parts, alkaloids accounted for 4.0%, 3.6%, 5.1%, and 4.5%; flavonoids accounted for 0.7%, 27.2%, 5.6%, 1.2%; terpenes accounted for 20.1%, 2.1%, 2.6%, 2.5%. Furthermore, the abundance of phenols, phenylpropanoids, and lipids metabolites sequentially accounted for 2.3-4.4%, 0.5-1.8%, and 2.4-5.3%. These results have improved our understanding of metabolites and provided a reference for research on the medicinal and edible value of Morus alba L. In addition, the study reveals the correlation between the components of Traditional Chinese medicine and the basic theory of TCM properties and reinterprets the ancient wisdom in the world's traditional herbs through the perspective of modern science.
桑是一种传统的药用和食用植物。它富含许多重要的生物活性成分。然而，关于这些成分的系统信息却很少。本研究以桑白皮、桑叶、桑椹和桑枝为研究对象。采用超高效液相色谱-质谱联用（UHPLC-MS）技术研究了桑属植物的初生和次生代谢产物。共鉴定出 802 种代谢产物，分为 10 个不同类别。代谢产物的相关性分析、层次聚类分析和主成分分析表明，不同部位的样品之间存在显著差异。在不同药用部位，生物碱分别占 4.0%、3.6%、5.1%和 4.5%；黄酮类化合物分别占 0.7%、27.2%、5.6%、1.2%；萜类化合物分别占 20.1%、2.1%、2.6%、2.5%。此外，酚类、苯丙素类和脂类代谢物的丰度依次为 2.3-4.4%、0.5-1.8%和 2.4-5.3%。这些结果提高了我们对代谢产物的认识，为桑白皮的药用和食用价值研究提供了参考。此外，本研究通过现代科学的角度，揭示了中药成分与中药药性基本理论之间的相关性，重新诠释了世界传统草药中的古老智慧。
