Reddy Shreya, Brahmbhatt Hetal
Biology, Creighton University, Omaha, USA.
Psychiatry, Mercy General Hospital, Sacramento, USA.
Cureus. 2021 Nov 18;13(11):e19704. doi: 10.7759/cureus.19704. eCollection 2021 Nov.
Hailey-Hailey disease is a rare genetic disease that causes irregular blistering. The irregular blistering is also usually accompanied by skin lesions in the affected skin area. The symptoms and signs of Hailey-Hailey disease differ from one case to another. There is no one standard treatment method for Hailey-Hailey disease. However, there are certain treatment methods that do show some promise. This review will analyze the use and fruitfulness of surgical skin grafting, tacrolimus, and acitretin in multiple settings to treat Hailey-Hailey disease. Surgical skin grafting is done by removing the epidermis and a portion of the dermis, if not all of the dermis, healthy skin from a different part of the body, and transplanting it to the damaged area of the body. Acitretin is a retinoid that is a derivative of vitamin A that reduces abnormal differentiation of keratinocytes and inflammation which prove useful for helping skin diseases. Tacrolimus is an immunosuppressive drug that works by limiting the activity of the immune system to prevent it from producing substances that contribute to the redness and dryness of the skin, making it a candidate to be used for Hailey-Hailey disease treatment. The understood results of tacrolimus, acitretin, and surgical skin grafting on Hailey-Hailey disease are very limited and should be given more attention by healthcare leaders to the potential outcomes of these treatments on patients who have Hailey-Hailey disease.
黑利-黑利病是一种罕见的遗传病，会导致皮肤出现不规则水疱。这种不规则水疱通常还伴有患病皮肤区域的皮肤病变。黑利-黑利病的症状和体征因病例而异。对于黑利-黑利病，没有一种标准的治疗方法。然而，有一些治疗方法确实显示出了一定的前景。本综述将分析手术植皮、他克莫司和阿维A在多种情况下治疗黑利-黑利病的应用及效果。手术植皮是通过从身体的不同部位去除表皮和部分真皮（如果不是全部真皮），即健康皮肤，并将其移植到身体的受损部位来进行的。阿维A是一种类视黄醇，是维生素A的衍生物，可减少角质形成细胞的异常分化和炎症，这对治疗皮肤病很有用。他克莫司是一种免疫抑制药物，其作用是限制免疫系统的活性，以防止其产生导致皮肤发红和干燥的物质，使其成为治疗黑利-黑利病的候选药物。目前对于他克莫司、阿维A和手术植皮治疗黑利-黑利病的了解结果非常有限，医疗保健领域的领导者应更多地关注这些治疗方法对黑利-黑利病患者的潜在疗效。
