Prakasam Mythili, Locs Janis, Salma-Ancane Kristine, Loca Dagnija, Largeteau Alain, Berzina-Cimdina Liga
CNRS, Univ. Bordeaux, ICMCB, UPR 9048, F-33600 Pessac, France.
Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Pulka 3, LV-1007 Riga, Latvia.
J Funct Biomater. 2017 Sep 26;8(4):44. doi: 10.3390/jfb8040044.
Recent progress made in biomaterials and their clinical applications is well known. In the last five decades, great advances have been made in the field of biomaterials, including ceramics, glasses, polymers, composites, glass-ceramics and metal alloys. A variety of bioimplants are currently used in either one of the aforesaid forms. Some of these materials are designed to degrade or to be resorbed inside the body rather than removing the implant after its function is served. Many properties such as mechanical properties, non-toxicity, surface modification, degradation rate, biocompatibility, and corrosion rate and scaffold design are taken into consideration. The current review focuses on state-of-the-art biodegradable bioceramics, polymers, metal alloys and a few implants that employ bioresorbable/biodegradable materials. The essential functions, properties and their critical factors are discussed in detail, in addition to their challenges to be overcome.
生物材料及其临床应用方面的最新进展众所周知。在过去的五十年里,生物材料领域取得了巨大进展,包括陶瓷、玻璃、聚合物、复合材料、微晶玻璃和金属合金。目前,各种生物植入物都以上述形式之一使用。其中一些材料被设计成在体内降解或被吸收,而不是在植入物完成其功能后将其取出。许多性能,如机械性能、无毒性、表面改性、降解速率、生物相容性、腐蚀速率和支架设计等都被考虑在内。本综述重点关注最先进的可生物降解生物陶瓷、聚合物、金属合金以及一些采用生物可吸收/可生物降解材料的植入物。除了需要克服的挑战外,还详细讨论了其基本功能、性能及其关键因素。