Department of Psychiatry, McGill University, Montreal, Quebec, Canada; Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada; Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Neurosci Biobehav Rev. 2022 Jan;132:37-49. doi: 10.1016/j.neubiorev.2021.11.034. Epub 2021 Nov 23.
Schizophrenia is characterized by cognitive impairments and widespread structural brain abnormalities. Brain structure-cognition associations have been extensively studied in schizophrenia, typically involving individual cognitive domains or brain regions of interest. Findings in overlapping and diffuse brain regions may point to structural alterations in large-scale brain networks. We performed a systematic review and meta-analysis examining whether brain structure-cognition associations can be explained in terms of biologically meaningful brain networks. Of 7,261 screened articles, 88 were included in a series of meta-analyses assessing publication bias, heterogeneity, and study quality. Significant associations were found between overall brain structure and eight MATRICS-inspired cognitive domains. Brain structure mapped onto the seven Yeo functionally defined networks and extraneous structures (amygdala, hippocampus, and cerebellum) typically showed associations with conceptually related cognitive domains, with higher-level domains (e.g., executive function, social cognition) associated with more networks. These findings synthesize the extensive literature on brain structure and cognition in schizophrenia from a contemporary network neuroscience perspective and suggest that brain structure-cognition associations in schizophrenia may follow functional network architecture.
精神分裂症的特征是认知障碍和广泛的结构脑异常。在精神分裂症中，大脑结构与认知的关联已经得到了广泛的研究，通常涉及单个认知领域或感兴趣的脑区。在重叠和弥散的脑区中发现的结果可能指向大规模脑网络的结构改变。我们进行了一项系统评价和荟萃分析，研究大脑结构与认知的关联是否可以用有生物学意义的大脑网络来解释。在筛选出的 7261 篇文章中，有 88 篇被纳入一系列荟萃分析中，以评估发表偏倚、异质性和研究质量。总体脑结构与八个受 MATRICS 启发的认知领域之间存在显著关联。大脑结构映射到七个 Yeo 功能定义的网络和多余的结构（杏仁核、海马体和小脑）通常与概念上相关的认知领域相关联，较高层次的领域（例如，执行功能、社会认知）与更多的网络相关联。这些发现从当代网络神经科学的角度综合了精神分裂症中关于大脑结构和认知的广泛文献，并表明精神分裂症中大脑结构与认知的关联可能遵循功能网络结构。
