眼部瘢痕性类天疱疮中的人类白细胞抗原
HLA antigens in ocular cicatricial pemphigoid.
作者信息
Mondino B J, Brown S I, Rabin B S
出版信息
Br J Ophthalmol. 1978 Apr;62(4):265-7. doi: 10.1136/bjo.62.4.265.
HLA antigen frequencies were studied in 20 patients with ocular cicatricial pemphigoid and 245 normal persons. HLA-B12 demonstrated an increased frequency of 45% in patients with ocular cicatricial pemphigoid which was statistically significant when compared to a frequency of 19.6% in the general population (P less than 0.02). In patients with ocular cicatricial pemphigoid the prevalance of HLA-A3 was increased to 35% when compared to 22.9% in the general population, but this was not statistically significant. The frequency of finding either HLA-A3 or B12 in patients with ocular cicatricial pemphigoid was increased to 75% in comparison with 38.8% in the general population (P less than 0.005). The present study suggests that HLA-B12 and possibly HLA-A3 are genetic markers for ocular cicatricial pemphigoid.
对20例眼部瘢痕性类天疱疮患者和245名正常人的HLA抗原频率进行了研究。眼部瘢痕性类天疱疮患者中HLA - B12的频率增加了45%，与普通人群中19.6%的频率相比具有统计学意义（P小于0.02）。与普通人群中22.9%相比，眼部瘢痕性类天疱疮患者中HLA - A3的患病率增加到35%，但这无统计学意义。眼部瘢痕性类天疱疮患者中发现HLA - A3或B12的频率与普通人群中38.8%相比增加到75%（P小于0.005）。本研究表明，HLA - B12以及可能的HLA - A3是眼部瘢痕性类天疱疮的遗传标记。
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