Shin D H, Becker B, Waltman S R, Palmberg P F, Bell E
Arch Ophthalmol. 1977 Feb;95(2):224-5. doi: 10.1001/archopht.1977.04450020026003.
HLA-B12 antigen was found in 50% and HLA-B7 was present in 49% of patients with primary open-angle glaucoma. Either one of the antigens B12 or B7 was noted in 88% of such glaucoma patients. The prevalences of B12, B7, or of either antigen were much greater in patients with primary open-angle glaucoma than in the general population or in patients with normal intraocular pressure. The prevalences in patients with ocular hypertension (IOP greater than 20 mm Hg) were intermediate between the ocular normotensives and the patients with primary open-angle glaucoma. The close association between HLA-B12 and HLA-B7 and primary open-angle glaucoma suggested immunologic components of the disease and possible convenient genetic markers.
在原发性开角型青光眼患者中，50%的患者发现有HLA - B12抗原，49%的患者存在HLA - B7。88%的此类青光眼患者发现有抗原B12或B7。原发性开角型青光眼患者中B12、B7或任一抗原的患病率远高于普通人群或眼压正常的患者。高眼压（眼压大于20 mmHg）患者的患病率介于眼压正常者和原发性开角型青光眼患者之间。HLA - B12和HLA - B7与原发性开角型青光眼之间的密切关联提示了该疾病的免疫成分以及可能便捷的遗传标记。
