Department of Ophthalmology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.
Korean J Ophthalmol. 2022 Feb;36(1):66-73. doi: 10.3341/kjo.2021.0155. Epub 2021 Nov 26.
To determine the clinical significance of choroidal thickness and evaluate changes in choroidal thickness over time in eyes affected by ocular ischemic syndrome (OIS).
Medical records of 16 patients diagnosed with OIS between November 2017 and August 2019 were retrospectively reviewed. In every nine areas of the Early Treatment Diabetic Retinopathy Study grid, we compared the differences in choroidal thickness between the eyes with OIS and unaffected eyes, and its change in the OIS eyes during the follow-up period using swept-source optical coherence tomography. We analyzed the best-corrected visual acuity, intraocular pressure, fluorescein angiography (FAG) parameters, systemic diseases, and the duration of symptoms. Correlation between FAG parameters and the choroidal thickness value ratio in the OIS eyes and the unaffected eyes, and changes in the choroidal thickness in the OIS eyes during follow-up were investigated.
Median age of the subjects was 67.5 years. In the OIS eyes, all FAG parameters were delayed at the initial examination. Best-corrected visual acuity and intraocular pressure were significantly different between the OIS and unaffected eyes. While the choroidal thickness in every nine areas of Early Treatment Diabetic Retinopathy Study in the OIS eyes was lesser than the unaffected eyes, the choroidal thickness of inner temporal, outer nasal, and outer temporal area showed statistically significant difference. During follow-up, changes in choroidal thickness of OIS eyes as well as correlation between the FAG parameters and the choroidal thickness value ratio between the OIS eyes and the unaffected eyes were not found to be statistically significant.
The choroidal thickness of the eyes with OIS was significantly less compared with the unaffected eyes. We inferred that choroidal thinning takes place in the early phase of the disease as the changes in choroidal thickness during the follow-up period were not significant.
确定脉络膜厚度的临床意义，并评估眼缺血综合征（OIS）患者眼中脉络膜厚度随时间的变化。
回顾性分析 2017 年 11 月至 2019 年 8 月期间诊断为 OIS 的 16 例患者的病历。在每个早期治疗糖尿病性视网膜病变研究网格的 9 个区域中，我们比较了 OIS 眼和未受影响眼之间脉络膜厚度的差异，并使用扫频源光学相干断层扫描（OCT）比较了 OIS 眼在随访期间的变化。我们分析了最佳矫正视力、眼压、荧光素血管造影（FAG）参数、系统性疾病和症状持续时间。分析了 OIS 眼和未受影响眼的 FAG 参数与脉络膜厚度比值的相关性，以及 OIS 眼在随访期间脉络膜厚度的变化。
研究对象的中位年龄为 67.5 岁。在 OIS 眼中，所有 FAG 参数在初始检查时均延迟。OIS 眼和未受影响眼的最佳矫正视力和眼压均有显著差异。虽然 OIS 眼每个早期治疗糖尿病性视网膜病变研究网格的 9 个区域的脉络膜厚度均小于未受影响眼，但内颞、外鼻和外颞区域的脉络膜厚度差异具有统计学意义。在随访期间，OIS 眼的脉络膜厚度变化以及 FAG 参数与 OIS 眼和未受影响眼的脉络膜厚度比值之间的相关性均无统计学意义。
与未受影响的眼睛相比，OIS 眼睛的脉络膜厚度明显变薄。我们推断，在疾病的早期阶段就发生了脉络膜变薄，因为在随访期间脉络膜厚度的变化并不显著。
