Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, United States of America.
Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, United States of America.
J Geriatr Oncol. 2022 Apr;13(3):282-286. doi: 10.1016/j.jgo.2021.10.011. Epub 2021 Nov 22.
Vulvar dermatoses are often debilitating chronic skin conditions associated with pain and pruritus. In oncologic patients, cancer treatments can precipitate and exacerbate vulvar dermatoses. Cytotoxic chemotherapy, hormonal therapies, and local pelvic radiation therapy can lead to vulvar symptoms, and cancer treatment-induced vulvar conditions include graft-versus-host-disease and radiation dermatitis. There have also been reports of lichen sclerosus development or exacerbation secondary to hormonal therapy and immune checkpoint inhibitors, attributed to proposed hormonal and immunologic pathogenesis of lichen sclerosus. Early recognition and treatment of these conditions can significantly improve quality of life. In this review, we summarize the clinical features and management characteristics of six types of common vulvar dermatoses that may present in the oncologic patient.
外阴皮肤病常为导致疼痛和瘙痒的使人虚弱的慢性皮肤疾病。在肿瘤患者中，癌症治疗可引发和加重外阴皮肤病。细胞毒性化疗、激素治疗和局部盆腔放射治疗可导致外阴症状，癌症治疗引起的外阴疾病包括移植物抗宿主病和放射性皮炎。也有报道称，由于外阴硬化性苔藓的激素和免疫发病机制，激素治疗和免疫检查点抑制剂可导致其发生或加重。早期识别和治疗这些疾病可显著改善生活质量。在这篇综述中，我们总结了 6 种常见外阴皮肤病的临床特征和治疗特点，这些疾病可能会出现在肿瘤患者中。
