Tashiro Syoichi, Tsuji Osahiko, Shinozaki Munehisa, Shibata Takahiro, Yoshida Takashi, Tomioka Yohei, Unai Kei, Kondo Takahiro, Itakura Go, Kobayashi Yoshiomi, Yasuda Akimasa, Nori Satoshi, Fujiyoshi Kanehiro, Nagoshi Narihito, Kawakami Michiyuki, Uemura Osamu, Yamada Shin, Tsuji Tetsuya, Okano Hideyuki, Nakamura Masaya
Department of Rehabilitation Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Department of Rehabilitation Medicine, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
NPJ Regen Med. 2021 Nov 25;6(1):81. doi: 10.1038/s41536-021-00191-7.
Stem cell-based regenerative therapy has opened an avenue for functional recovery of patients with spinal cord injury (SCI). Regenerative rehabilitation is attracting wide attention owing to its synergistic effects, feasibility, non-invasiveness, and diverse and systemic properties. In this review article, we summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of SCI. Although conventional rehabilitative methods have commonly been implemented alone, especially in studies of acute-to-subacute SCI, the combinatorial effects of intensive and advanced methods, including various neurorehabilitative approaches, have also been reported. Separating the concept of combined rehabilitation from regenerative rehabilitation, we suggest that the main roles of regenerative rehabilitation can be categorized as conditioning/reconditioning, functional training, and physical exercise, all of which are indispensable for enhancing functional recovery achieved using stem cell therapies.
基于干细胞的再生疗法为脊髓损伤（SCI）患者的功能恢复开辟了一条途径。再生康复因其协同效应、可行性、非侵入性以及多样和系统性的特性而备受关注。在这篇综述文章中，我们总结了康复的特点，描述了联合治疗的机制，并在SCI的背景下讨论了再生康复。尽管传统的康复方法通常单独实施，特别是在急性至亚急性SCI的研究中，但也有报道称包括各种神经康复方法在内的强化和先进方法具有联合效应。我们将联合康复的概念与再生康复区分开来，认为再生康复的主要作用可分为调节/再调节、功能训练和体育锻炼，所有这些对于提高使用干细胞疗法实现的功能恢复都是不可或缺的。
