Liu Ruxing, Peng Bo, Yuan Jie, Hu Jiahao, Yang Jianxin, Shan Nan, Li Qichao, Zhao Bin, Xu Chaojian, Wang Yongfeng
Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.
Department of Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Second Hospital of Shanxi Medical University, Taiyuan, China.
Front Genet. 2024 Feb 6;15:1327216. doi: 10.3389/fgene.2024.1327216. eCollection 2024.
The aim of this study was to conduct a bibliometric analysis of the literature on stem cell treatment for spinal cord injury to gain an intuitive understanding of how the field is progressing, discover topics of interest, and determine what development trends are emerging in this field. Spinal cord injury and its complications often cause an enormous economic burden, and postinjury repair and treatment have always been challenging in clinical and scientific research. Stem cell therapy for spinal cord injury can prevent immune rejection and induce the release of neuroprotective and anti-inflammatory factors to reduce the production of stress-related proteins, reactive oxygen species, and inflammatory reactions. We analyzed the number and quality of publications in the field of stem cell therapy in spinal cord injury between 2018.01.01 and 2023.06.30 in the core collection database of Web of Science. CiteSpace and VOSviewer were used to sort and summarize these studies by country, institution, authors' publications, and collaborative networks. In addition, the research topics of interest were identified and summarized. This study ultimately included 2,150 valid papers, with the number of publications showing a gradual upward trend. The country, institution, author and journal with the greatest number of publications and citations are China, the Chinese Academy of Sciences, Dai JW, and the International Journal of Molecular Sciences, respectively. The top three high-frequency keyword clusters were hereditary paraplegia, reactive astrocytes and tissue engineering. With the help of visual analysis, we identified general trends and research topics of interest in the field of spinal cord injury over the last 5 years. Our findings suggest that stem cell transplantation for spinal cord injury and exosome therapy may be a focus of future research. This study provides a foundation for future research on stem cell therapy as well as clinical efforts in this field.
本研究的目的是对脊髓损伤干细胞治疗的文献进行文献计量分析,以直观了解该领域的进展情况,发现感兴趣的主题,并确定该领域正在出现的发展趋势。脊髓损伤及其并发症往往会造成巨大的经济负担,损伤后的修复和治疗在临床和科研中一直具有挑战性。脊髓损伤的干细胞疗法可以防止免疫排斥,并诱导神经保护和抗炎因子的释放,以减少应激相关蛋白、活性氧和炎症反应的产生。我们分析了2018年1月1日至2023年6月30日期间Web of Science核心合集数据库中脊髓损伤干细胞治疗领域的出版物数量和质量。使用CiteSpace和VOSviewer按国家、机构、作者出版物和合作网络对这些研究进行分类和总结。此外,还确定并总结了感兴趣的研究主题。本研究最终纳入了2150篇有效论文,出版物数量呈逐渐上升趋势。出版物和被引次数最多的国家、机构、作者和期刊分别是中国、中国科学院、戴建武和《国际分子科学杂志》。高频关键词聚类排名前三的是遗传性截瘫、反应性星形胶质细胞和组织工程。借助可视化分析,我们确定了过去5年脊髓损伤领域的总体趋势和感兴趣的研究主题。我们的研究结果表明,脊髓损伤的干细胞移植和外泌体疗法可能是未来研究的重点。本研究为该领域未来的干细胞治疗研究以及临床工作提供了基础。
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