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脊髓损伤的干细胞治疗研究:2018 - 2023年文献计量与可视化分析

Research on stem cell therapy for spinal cord injury: a bibliometric and visual analysis from 2018-2023.

作者信息

Liu Ruxing, Peng Bo, Yuan Jie, Hu Jiahao, Yang Jianxin, Shan Nan, Li Qichao, Zhao Bin, Xu Chaojian, Wang Yongfeng

机构信息

Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.

Department of Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Second Hospital of Shanxi Medical University, Taiyuan, China.

出版信息

Front Genet. 2024 Feb 6;15:1327216. doi: 10.3389/fgene.2024.1327216. eCollection 2024.


DOI:10.3389/fgene.2024.1327216
PMID:38380424
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10877028/
Abstract

The aim of this study was to conduct a bibliometric analysis of the literature on stem cell treatment for spinal cord injury to gain an intuitive understanding of how the field is progressing, discover topics of interest, and determine what development trends are emerging in this field. Spinal cord injury and its complications often cause an enormous economic burden, and postinjury repair and treatment have always been challenging in clinical and scientific research. Stem cell therapy for spinal cord injury can prevent immune rejection and induce the release of neuroprotective and anti-inflammatory factors to reduce the production of stress-related proteins, reactive oxygen species, and inflammatory reactions. We analyzed the number and quality of publications in the field of stem cell therapy in spinal cord injury between 2018.01.01 and 2023.06.30 in the core collection database of Web of Science. CiteSpace and VOSviewer were used to sort and summarize these studies by country, institution, authors' publications, and collaborative networks. In addition, the research topics of interest were identified and summarized. This study ultimately included 2,150 valid papers, with the number of publications showing a gradual upward trend. The country, institution, author and journal with the greatest number of publications and citations are China, the Chinese Academy of Sciences, Dai JW, and the International Journal of Molecular Sciences, respectively. The top three high-frequency keyword clusters were hereditary paraplegia, reactive astrocytes and tissue engineering. With the help of visual analysis, we identified general trends and research topics of interest in the field of spinal cord injury over the last 5 years. Our findings suggest that stem cell transplantation for spinal cord injury and exosome therapy may be a focus of future research. This study provides a foundation for future research on stem cell therapy as well as clinical efforts in this field.

摘要

本研究的目的是对脊髓损伤干细胞治疗的文献进行文献计量分析,以直观了解该领域的进展情况,发现感兴趣的主题,并确定该领域正在出现的发展趋势。脊髓损伤及其并发症往往会造成巨大的经济负担,损伤后的修复和治疗在临床和科研中一直具有挑战性。脊髓损伤的干细胞疗法可以防止免疫排斥,并诱导神经保护和抗炎因子的释放,以减少应激相关蛋白、活性氧和炎症反应的产生。我们分析了2018年1月1日至2023年6月30日期间Web of Science核心合集数据库中脊髓损伤干细胞治疗领域的出版物数量和质量。使用CiteSpace和VOSviewer按国家、机构、作者出版物和合作网络对这些研究进行分类和总结。此外,还确定并总结了感兴趣的研究主题。本研究最终纳入了2150篇有效论文,出版物数量呈逐渐上升趋势。出版物和被引次数最多的国家、机构、作者和期刊分别是中国、中国科学院、戴建武和《国际分子科学杂志》。高频关键词聚类排名前三的是遗传性截瘫、反应性星形胶质细胞和组织工程。借助可视化分析,我们确定了过去5年脊髓损伤领域的总体趋势和感兴趣的研究主题。我们的研究结果表明,脊髓损伤的干细胞移植和外泌体疗法可能是未来研究的重点。本研究为该领域未来的干细胞治疗研究以及临床工作提供了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/c9934b19924c/fgene-15-1327216-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/c46d5221c6c2/fgene-15-1327216-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/4f64f18e8efe/fgene-15-1327216-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/506e7f82f470/fgene-15-1327216-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/9eee1d42c6e6/fgene-15-1327216-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/6e94f3942272/fgene-15-1327216-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/15ccc1de8fac/fgene-15-1327216-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/c9934b19924c/fgene-15-1327216-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/c46d5221c6c2/fgene-15-1327216-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/4f64f18e8efe/fgene-15-1327216-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/506e7f82f470/fgene-15-1327216-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/9eee1d42c6e6/fgene-15-1327216-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/6e94f3942272/fgene-15-1327216-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/15ccc1de8fac/fgene-15-1327216-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb1b/10877028/c9934b19924c/fgene-15-1327216-g007.jpg

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[7]
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引用本文的文献

[1]
Advances and New Therapies in Traumatic Spinal Cord Injury.

J Clin Med. 2025-3-24

[2]
Mapping the Knowledge Landscape of and Emerging Future Trends in Stem Cell Therapy for Osteoarthritis: A Bibliometric Analysis of the Literature From 1998 to 2024.

J Multidiscip Healthc. 2025-3-4

[3]
Global Stem Cell Research in Orthopaedics: A Bibliometric Study from 1995 to 2020.

Indian J Orthop. 2024-5-2

[4]
The top 100 most cited articles on mucopolysaccharidoses: a bibliometric analysis.

Front Genet. 2024-4-12

本文引用的文献

[1]
Insight into Nrf2: a bibliometric and visual analysis from 2000 to 2022.

Front Genet. 2023-9-15

[2]
Bibliometric analysis of stem cells for spinal cord injury: current status and emerging frontiers.

Front Pharmacol. 2023-7-18

[3]
Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3/JAK2/STAT3 axis and improve the outcome of spinal cord injury.

J Neuroinflammation. 2023-6-30

[4]
Clinical Efficacy and Safety of the Intra-articular Injection of Autologous Adipose-Derived Mesenchymal Stem Cells for Knee Osteoarthritis: A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial.

Am J Sports Med. 2023-7

[5]
Bibliometric Analysis of Research Themes and Trends of the Co-Occurrence of Autism and ADHD.

Neuropsychiatr Dis Treat. 2023-4-24

[6]
Neutrophil extracellular traps in autoimmune diseases: Analysis of the knowledge map.

Front Immunol. 2023

[7]
Bibliometric and visualization analysis of literature relating to diabetic erectile dysfunction.

Front Endocrinol (Lausanne). 2022

[8]
3D Gelatin Microsphere Scaffolds Promote Functional Recovery after Spinal Cord Hemisection in Rats.

Adv Sci (Weinh). 2023-1

[9]
Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat.

Bioact Mater. 2022-11-23

[10]
Depletion of SASH1, an astrocyte differentiation-related gene, contributes to functional recovery in spinal cord injury.

CNS Neurosci Ther. 2023-1

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