Shen Wenke, Xu Wenyun, Chen Hui
College of International Vocational Education, Shanghai Polytechnic University No. 2360, Jinhai Road, Pudong New Area, Shanghai 201209, China.
Department of Anesthesiology, Shanghai Changzheng Hospital Shanghai 200003, China.
Am J Clin Exp Immunol. 2021 Oct 15;10(3):65-70. eCollection 2021.
A scar is a local symptom, which results from severe physical, biological and chemical damage to human skin and soft tissue. Scars can affect both skin appearance and function. The affected skin or soft tissue cannot be completely repaired normally by itself and is replaced by formed fibrous tissue. Patients with scars can develop physical pain and mental conditions, especially those with scars left after burns, scalds and severe traumas. The scar proliferation phase can be up to several years which could be almost unbearable for patients. Also, the atrophic period afterwards makes the patient's face unrecognizable and dysfunctional, causing great physical and mental impairment. Therefore, scar repair is of great clinical importance for patients, and understanding the immunological mechanisms of scar repair is an important prerequisite for the effective treatment of scars. This study is a systematic review of current research advances about the immunological mechanisms of scar repair, so as to provide a reference for the selection of regimens in clinical treatment.
瘢痕是一种局部症状，它是由人体皮肤和软组织受到严重的物理、生物和化学损伤所导致的。瘢痕会影响皮肤的外观和功能。受影响的皮肤或软组织自身无法完全正常修复，而是由形成的纤维组织所替代。有瘢痕的患者会出现身体疼痛和心理问题，尤其是那些有烧伤、烫伤和严重创伤后留下瘢痕的患者。瘢痕增生期可持续数年，这对患者来说几乎难以忍受。此外，随后的萎缩期会使患者面部变形且功能失调，造成极大的身心损害。因此，瘢痕修复对患者具有重要的临床意义，而了解瘢痕修复的免疫机制是有效治疗瘢痕的重要前提。本研究是对瘢痕修复免疫机制当前研究进展的系统综述，以便为临床治疗方案的选择提供参考。
