Sharma Pragya, Mishra Suruchi, Basu Saurav, Kumar Rajesh, Tanwar Neha
Community Medicine, Maulana Azad Medical College, Delhi, IND.
Cureus. 2021 Oct 27;13(10):e19070. doi: 10.7759/cureus.19070. eCollection 2021 Oct.
Introduction This study aimed to determine the breakthrough infection rate of coronavirus disease 2019 (COVID-19) (severe acute respiratory syndrome coronavirus 2 {SARS-CoV-2}) infection in healthcare workers (HCWs) vaccinated with either BBV152 or AZD1222 (ChAdOx1-S) vaccine. Methods A cross-sectional analysis was conducted at a medical college and hospital complex in Delhi, India, through telephonic interviews among HCWs who had received at least one dose of a COVID-19 vaccine during January-March 2021. Breakthrough infections were operationally defined as the occurrence of COVID-19 infection ≥14 days after administration of two doses of either COVID-19 vaccine. Data were entered in Epidata 3.1 (Odense, Denmark: EpiData Association) (single entered) and analyzed with IBM SPSS version 25 (Armonk, NY: IBM Corp.). A p-value < 0.05 was considered statistically significant. Results We enrolled 325 HCWs with a mean (SD) age of 29.1 (9.9) years including 211 (64.9%) males and 114 (35.1%) females. A total of 37 (13.3%, 95% CI 9.8, 17.7) COVID-19 breakthrough infections were observed in the HCWs. Additionally, 20 (6.1%) non-breakthrough infections were reported in the HCWs who were vaccinated with at least a single dose of a COVID-19 vaccine, or both doses, but prior to 14 days since the administration of the second dose. Most breakthrough infections were mild without needing supplemental oxygen for recovery. Conclusion Nearly one in seven HCWs experienced a COVID-19 breakthrough infection in the present study. A history of SARS-CoV-2 natural infection followed by at least one dose of COVID-19 vaccination was associated with significant protection against breakthrough infections.
引言 本研究旨在确定接种BBV152或AZD1222（ChAdOx1-S）疫苗的医护人员中2019冠状病毒病（COVID-19，严重急性呼吸综合征冠状病毒2{SARS-CoV-2}）感染的突破性感染率。方法 在印度德里的一所医学院和医院综合设施中进行了一项横断面分析，通过电话访谈2021年1月至3月期间至少接种过一剂COVID-19疫苗的医护人员。突破性感染在操作上定义为在接种两剂任何一种COVID-19疫苗后≥14天发生的COVID-19感染。数据录入Epidata 3.1（丹麦欧登塞：EpiData协会）（单录入），并使用IBM SPSS 25版（纽约州阿蒙克：IBM公司）进行分析。p值<0.05被认为具有统计学意义。结果 我们纳入了325名医护人员，平均（标准差）年龄为29.1（9.9）岁，其中男性211名（64.9%），女性114名（35.1%）。在医护人员中总共观察到37例（13.3%，95%置信区间9.8，17.7）COVID-19突破性感染。此外，在接种了至少一剂COVID-19疫苗或两剂但在第二剂接种后14天之前的医护人员中报告了20例（6.1%）非突破性感染。大多数突破性感染为轻症，恢复时无需补充氧气。结论 在本研究中，近七分之一的医护人员经历了COVID-19突破性感染。SARS-CoV-2自然感染史后至少接种一剂COVID-19疫苗与预防突破性感染的显著保护作用相关。
