Nataprawira Heda Melinda, Septiane Indah, Sudarwati Sri, Wulandari Diah Asri
Department of Child Health, Hasan Sadikin General Hospital/Faculty of Medicine, Universitas Padjadjaran, Indonesia.
Respir Med Case Rep. 2021 Nov 12;34:101544. doi: 10.1016/j.rmcr.2021.101544. eCollection 2021.
Few reports are available on children with pre-extensively drug-resistant tuberculosis (pre-XDR-TB), which is defined as resistant to both isoniazid and rifampicin plus resistance to either a fluoroquinolone or a second-line injectable drug. Pre-XDR-TB treatment for children usually has been individualized based on drug susceptibility test (DST) results, but treatment remains challenging due to the lack of studies based on existing treatment guidelines in children and lack of availability of the new drugs. We report two cases of pre-XDR-TB in children who have responded well to individualized treatment regimens. Because toxic drugs are used for long duration, close monitoring of adverse drug reactions is important.
关于广泛耐药结核病前期（pre-XDR-TB）儿童的报告很少，pre-XDR-TB的定义为对异烟肼和利福平耐药，同时对氟喹诺酮类药物或二线注射用药物中的一种耐药。儿童pre-XDR-TB的治疗通常根据药敏试验（DST）结果进行个体化，但由于缺乏基于现有儿童治疗指南的研究以及新药供应不足，治疗仍然具有挑战性。我们报告了两例对个体化治疗方案反应良好的儿童pre-XDR-TB病例。由于使用有毒药物的时间较长，密切监测药物不良反应很重要。
