Meng Lingchang, Wang Qiaolei, Wang Lai, Zhao Zhen, Xin Gui-Zhong, Zheng Zuguo, Zhou Ping, Li Ping, Jiang Yan, Li Hui-Jun
State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjia Lane, Nanjing, 210009, China.
College of Chemical Engineering, Nanjing Forestry University, 159 Longpan Road, Nanjing, 210037, China.
Mater Today Bio. 2021 Nov 12;12:100157. doi: 10.1016/j.mtbio.2021.100157. eCollection 2021 Sep.
Drug-induced liver injury (DILI) is a challenging clinical problem with respect to both diagnosis and management. As a newly emerging biomarker of liver injury, miR122 shows great potential in early and sensitive detection of DILI. Glycyrrhetinic acid (GA) possesses desirable therapeutic effect on DILI, but its certain dose-dependent side effects after long-term and/or high-dose administration limit its clinical application. In this study, in order to improve the precise diagnosis and effective treatment of DILI, GA loaded all-in-one theranostic nanoplatform was designed by assembling of upconversion nanoparticles and gold nanocages. As a proof of concept, we demonstrated the applicability of this single-wavelength laser-triggered theranostic nanoplatform for the spatiotemporally controllable imaging of DILI and miR122-controlled on-demand drug release and . This novel nanoplatform opens a promising avenue for the clinical diagnosis and treatment of DILI.
药物性肝损伤（DILI）在诊断和管理方面都是一个具有挑战性的临床问题。作为一种新出现的肝损伤生物标志物，miR122在DILI的早期和灵敏检测中显示出巨大潜力。甘草次酸（GA）对DILI具有良好的治疗效果，但长期和/或高剂量给药后其一定的剂量依赖性副作用限制了其临床应用。在本研究中，为了改善DILI的精确诊断和有效治疗，通过组装上转换纳米颗粒和金纳米笼设计了负载GA的一体化诊疗纳米平台。作为概念验证，我们证明了这种单波长激光触发的诊疗纳米平台在DILI的时空可控成像以及miR122控制的按需药物释放方面的适用性。这种新型纳米平台为DILI的临床诊断和治疗开辟了一条有前景的途径。
