一种流体动力可再填充的折纸心脏袋，用于在大鼠和猪中微创递送细胞疗法。
A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs.
机构信息
Department of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27695, USA.
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Med. 2021 Nov 12;2(11):1253-1268. doi: 10.1016/j.medj.2021.10.001. Epub 2021 Nov 2.
BACKGROUND
Cardiac repair after heart injury remains a big challenge and current drug delivery to the heart is suboptimal. Repeated dosing of therapeutics is difficult due to the invasive nature of such procedures.
METHODS
We developed a fluid-driven heart pouch with a memory-shaped microfabricated lattice structure inspired by origami. The origami structure allowed minimally invasive delivery of the pouch to the heart with two small incisions and can be refilled multiple times with the therapeutic of choice.
FINDINGS
We tested the pouch's ability to deliver mesenchymal stem cells (MSCs) in a rodent model of acute myocardial infarction and demonstrated the feasibility of minimally invasive delivery in a swine model. The pouch's semi-permeable membrane successfully protected delivered cells from their surroundings, maintaining their viability while releasing paracrine factors to the infarcted site for cardiac repair.
CONCLUSIONS
In summary, we developed a fluid-driven heart pouch with a memory-shaped microfabricated lattice structure inspired by origami. The origami structure allowed minimally invasive delivery of the pouch to the heart with two small incisions and can be refilled with the therapeutic of choice.
背景
心脏损伤后的修复仍然是一个巨大的挑战，目前心脏的药物输送效果并不理想。由于这些手术的侵入性，治疗药物的重复给药很困难。
方法
我们开发了一种基于折纸启发的具有记忆形状微加工格子结构的流体驱动心脏囊。折纸结构允许通过两个小切口微创地将囊输送到心脏，并且可以用选择的治疗药物多次填充。
发现
我们在急性心肌梗死的啮齿动物模型中测试了该囊输送间充质干细胞（MSCs）的能力，并在猪模型中证明了微创输送的可行性。该囊的半透膜成功地将输送的细胞与其周围环境隔离开来，在将旁分泌因子释放到梗死部位进行心脏修复的同时保持细胞活力。
结论
总之，我们开发了一种基于折纸启发的具有记忆形状微加工格子结构的流体驱动心脏囊。折纸结构允许通过两个小切口微创地将囊输送到心脏，并且可以用选择的治疗药物多次填充。
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