Department of Botany, Patna Science College, Patna, 800005, India.
Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Stem Cell Research Centre, Lucknow, 226014, Uttar Pradesh, India.
Mol Biol Rep. 2022 Jan;49(1):755-759. doi: 10.1007/s11033-021-06872-2. Epub 2021 Nov 25.
GTPase activating proteins (GAPs) were initially considered as the inhibitors of cell signaling pathways because of their nature to activate the intrinsic GTPase activity of the RhoGTPases. But recent studies of dysregulated GAPs in many cancers such as glioblastoma, colorectal cancer, breast cancer, and renal cancer have elucidated the important roles of GAPs in carcinogenesis and GAPs have been shown to perform multiple nonconventional functions in different contexts. We have discussed the recent developments in the roles played by different types of srGAPs (SLIT-ROBO Rho GTPase-activating proteins) in cancer.
GTP 酶激活蛋白（GAPs）最初被认为是细胞信号通路的抑制剂，因为它们具有激活 RhoGTPases 内在 GTP 酶活性的性质。但最近在许多癌症（如神经胶质瘤、结直肠癌、乳腺癌和肾癌）中失调的 GAPs 的研究阐明了 GAPs 在致癌作用中的重要作用，并且已经表明 GAPs 在不同的情况下具有多种非常规功能。我们讨论了不同类型的 srGAPs（SLIT-ROBO Rho GTPase 激活蛋白）在癌症中所扮演的角色的最新进展。
