来自 DJ-13 真菌的生物活性细胞松弛素。
Bioactive cytochalasans from the fungus Arthrinium arundinis DJ-13.
机构信息
Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.
Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.
出版信息
Phytochemistry. 2022 Feb;194:113009. doi: 10.1016/j.phytochem.2021.113009. Epub 2021 Nov 23.
The investigation of the metabolites from Arthrinium arundinis DJ-13 grown in solid medium revealed six undescribed cytochalasans, arundisins A-F and twelve known compounds. Their structures were initially investigated in detail by spectroscopic analyses and were further confirmed by X-crystallography and ECD experiments. In the in vitro bioassays, arundisins A and B showed cytotoxic activity against the MCF-7 breast cancer cell line with IC values of 18.82 ± 0.36 and 15.20 ± 0.42 μM, respectively. Arundisin F exhibited potent antibacterial activity against Escherichia coli with MIC of 8.00 μg/mL (kanamycin, 2.00 μg/mL), and arundisin D displayed gently antibacterial activity against Candida albicans with MIC of 32.00 μg/mL (Nystatin, 1.00 μg/mL).
从固态培养基中生长的节旋孢腔菌 DJ-13 中代谢产物的研究揭示了六种未描述的细胞松弛素，即 arundisins A-F 和十二种已知化合物。它们的结构最初通过光谱分析进行了详细研究，并通过 X 射线晶体学和 ECD 实验进一步证实。在体外生物测定中，arundisins A 和 B 对 MCF-7 乳腺癌细胞系表现出细胞毒性，IC 值分别为 18.82±0.36 和 15.20±0.42 μM。arundisin F 对大肠杆菌表现出很强的抗菌活性，MIC 为 8.00μg/mL（卡那霉素，2.00μg/mL），arundisin D 对白色念珠菌表现出温和的抗菌活性，MIC 为 32.00μg/mL（制霉菌素，1.00μg/mL）。
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