Department of Health, Ethics & Society, CAPHRI Care and Public Health Research Institute, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
Chemosphere. 2022 Jan;287(Pt 3):132255. doi: 10.1016/j.chemosphere.2021.132255. Epub 2021 Sep 16.
Though inconsistent, acute effects of ambient nitrogen oxides on cardiovascular mortality have been reported. Whereas, interactive roles of temperature on their relationships and joint effects of different indicators of nitrogen oxides were less studied. This study aimed to extrapolate the independent roles of ambient nitrogen oxides and temperature interactions on cardiovascular mortality.
Data on mortality, air pollutants, and meteorological factors in Shenzhen from 2013 to 2019 were collected. Three indicators including nitric oxide (NO), nitrogen dioxide (NO), and nitrogen oxides (NO) were studied. Adjusted generalized additive models (GAMs) were applied to analyse their associations with cardiovascular mortality in different groups.
The average daily concentrations of NO, NO, and NO were 11.7 μg/m, 30.7 μg/m, and 53.2 μg/m, respectively. Significant associations were shown with each indicator. Cumulative effects of nitrogen oxides were more obvious than distributed lag effects. Males, population under 65 years old, and population with stroke-related condition were more susceptible to nitrogen oxides. Adverse effects of nitrogen oxides were more significant at low temperature. Impacts of NO on cardiovascular mortality, and NO on stroke mortality were the most robust in the multi-pollutant models, whereas variations were shown in the other relationships.
Low levels of nitrogen oxides showed acute and adverse impacts and the interactive roles of temperature on cardiovascular mortality. Cumulative effects were most significant and joint effects of nitrogen oxides required more attention. Population under 65 years old and population with stroke-related health condition were susceptible, especially days at lower temperature.
尽管结果不一致，但已有研究报告表明，环境氮氧化物对心血管死亡率存在急性影响。然而，关于温度对它们之间关系的交互作用以及不同氮氧化物指标的联合效应的研究较少。本研究旨在推断环境氮氧化物和温度交互作用对心血管死亡率的独立作用。
收集了 2013 年至 2019 年深圳的死亡率、空气污染物和气象因素数据。研究了三种指标，包括一氧化氮（NO）、二氧化氮（NO）和氮氧化物（NO）。采用调整后的广义加性模型（GAMs）分析它们在不同组别的心血管死亡率中的相关性。
NO、NO 和 NO 的日均浓度分别为 11.7μg/m、30.7μg/m 和 53.2μg/m。每个指标都显示出与心血管死亡率的显著相关性。氮氧化物的累积效应比分布滞后效应更为明显。男性、65 岁以下人群和有中风相关疾病的人群对氮氧化物更为敏感。在低温下，氮氧化物的不利影响更为明显。在多污染物模型中，NO 对心血管死亡率的影响以及 NO 对中风死亡率的影响最为显著，而其他关系则存在变化。
低水平的氮氧化物表现出急性和不利影响，且温度对心血管死亡率存在交互作用。累积效应最为显著，需要更加关注氮氧化物的联合效应。65 岁以下人群和有中风相关健康状况的人群较为敏感，尤其是在低温天气下。
