Cantet Juan M, Yu Zhantao, Ríus Agustín G
Department of Animal Science, The University of Tennessee Institute of Agriculture (UTIA), Knoxville, TN 37996, USA.
Antibiotics (Basel). 2021 Oct 21;10(11):1285. doi: 10.3390/antibiotics10111285.
Physiological changes in animals exposed to elevated ambient temperature are characterized by the redistribution of blood toward the periphery to dissipate heat, with a consequent decline in blood flow and oxygen and nutrient supply to splanchnic tissues. Metabolic adaptations and gut dysfunction lead to oxidative stress, translocation of lumen contents, and release of proinflammatory mediators, activating a systemic inflammatory response. This review discusses the activation and development of the inflammatory response in heat-stressed models.
暴露于环境温度升高环境中的动物的生理变化特征为血液重新分配至外周以散热，结果导致流向内脏组织的血流、氧气和营养供应减少。代谢适应和肠道功能障碍会导致氧化应激、肠腔内容物移位以及促炎介质释放，从而激活全身炎症反应。本综述讨论了热应激模型中炎症反应的激活和发展。
